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Rat Anti-ITGAM Recombinant Antibody (10B618) (CBMAB-C0168-LY)


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Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
10B618
Antibody Isotype
IgG2b
Application
FC, IHC, IP

Basic Information

Immunogen
Thioglycollate-elicted Peritoneal Macrophages (TPM)
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Integrin Subunit Alpha M
Introduction
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Entrez Gene ID
Human3684
Mouse16409
UniProt ID
HumanP11215
MouseP05555
Alternative Names
Integrin Subunit Alpha M
Function
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295).
It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980).
In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity).
May play a role in mast cell development (By similarity).
Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Biological Process
Amyloid-beta clearanceISS:ARUK-UCL
Apoptotic signaling pathwayISS:ARUK-UCL
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathway involved in cell-cell signalingISS:ARUK-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules1 PublicationNAS:ARUK-UCL
Complement-mediated synapse pruningISS:ARUK-UCL
Ectodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Forebrain developmentISS:ARUK-UCL
Innate immune responseIEA:UniProtKB-KW
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Microglial cell activationISS:ARUK-UCL
Negative regulation of dopamine metabolic processISS:ARUK-UCL
Phagocytosis, engulfmentISS:ARUK-UCL
Positive regulation of hippocampal neuron apoptotic processISS:ARUK-UCL
Positive regulation of microglial cell mediated cytotoxicityISS:UniProtKB
Positive regulation of neuron deathISS:ARUK-UCL
Positive regulation of neutrophil degranulationManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of prostaglandin-E synthase activityISS:ARUK-UCL
Positive regulation of protein targeting to membraneISS:ARUK-UCL
Positive regulation of superoxide anion generationManual Assertion Based On ExperimentIGI:UniProtKB
Receptor-mediated endocytosisISS:ARUK-UCL
Vertebrate eye-specific patterningISS:ARUK-UCL
Cellular Location
Cell membrane; Membrane raft
Involvement in disease
Systemic lupus erythematosus 6 (SLEB6):
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Topology
Extracellular: 17-1104
Helical: 1105-1128
Cytoplasmic: 1129-1152
More Infomation

Hu, Y., Yu, Y., Dong, H., & Jiang, W. (2023). Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis. PeerJ, 11, e15437.

Intharanut, K., Suttanon, P., & Nathalang, O. (2023). Integrin Subunit Alpha M, ITGAM Nonsynonymous SNP Is Associated with Knee Osteoarthritis among Thais: A Case-Control Study. Current Issues in Molecular Biology, 45(5), 4168-4180.

Zhou, M., Wang, X., Shi, Y., Ding, Y., Li, X., Xie, T., ... & Fu, W. (2021). Deficiency of ITGAM attenuates experimental abdominal aortic aneurysm in mice. Journal of the American Heart Association, 10(7), e019900.

Liang, T., Chen, J., Xu, G., Zhang, Z., Xue, J., Zeng, H., ... & Zhan, X. (2021). TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma. Scientific Reports, 11(1), 19315.

Shi, D., Zhong, Z., Xu, R., Li, B., Li, J., Habib, U., ... & Li, M. (2019). Association of ITGAX and ITGAM gene polymorphisms with susceptibility to IgA nephropathy. Journal of Human Genetics, 64(9), 927-935.

Ramírez-Bello, J., Sun, C., Valencia-Pacheco, G., Singh, B., Barbosa-Cobos, R. E., Saavedra, M. A., ... & Nath, S. K. (2019). ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico. PLoS One, 14(11), e0224543.

Avery, J. T., Jimenez, R. V., Blake, J. L., Wright, T. T., Leόn-Ruiz, B., Schoeb, T. R., ... & Bullard, D. C. (2019). Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation. Mammalian Genome, 30, 245-259.

Gupta, V., Kumar, S., Pratap, A., Singh, R., Kumari, R., Kumar, S., ... & Misra, R. (2018). Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population. Lupus, 27(12), 1973-1979.

Herb, M., Gluschko, A., & Schramm, M. (2018). LC3-associated phagocytosis initiated by integrin ITGAM-ITGB2/Mac-1 enhances immunity to Listeria monocytogenes. Autophagy, 14(8), 1462-1464.

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For research use only. Not intended for any clinical use.

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