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Rat Anti-ITGAL Recombinant Antibody (M17/4) (CBMAB-1049-LY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
M17/4
Antibody Isotype
IgG2a
Application
Neutralization, FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Integrin Subunit Alpha L
Introduction
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity.
Entrez Gene ID
16408
UniProt ID
P24063
Alternative Names
Integrin Subunit Alpha L
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364).
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionBy SimilarityISS:BHF-UCL
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Inflammatory response1 PublicationNAS:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Memory T cell extravasationManual Assertion Based On ExperimentIDA:ARUK-UCL
PhagocytosisIEA:UniProtKB-KW
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 26-1090
Helical: 1091-1111
Cytoplasmic: 1112-1170
PTM
In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
More Infomation

Deng, T., Wang, C., Gao, C., Zhang, Q., & Guo, J. (2023). ITGAL as a prognostic biomarker correlated with immune infiltrates in melanoma. Frontiers in Oncology, 13, 1181537.

Wang, Q., Xiao, G., Li, N., Jiang, X., & Li, C. (2023). lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma. Aging (Albany NY), 15(10), 4510.

Zhang, J., Wang, H., Yuan, C., Wu, J., Xu, J., Chen, S., ... & He, Y. (2022). ITGAL as a prognostic biomarker correlated with immune infiltrates in gastric cancer. Frontiers in Cell and Developmental Biology, 10, 808212.

De Andrade Costa, A., Chatterjee, J., Cobb, O., Sanapala, S., Scheaffer, S., Guo, X., ... & Gutmann, D. H. (2022). RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth. Neuro-oncology, 24(1), 14-26.

Zhu, X., Liu, B., Ruan, Z., Chen, M., Li, C., Shi, H., ... & Dong, J. (2022). TMT-Based Quantitative Proteomic Analysis Reveals Downregulation of ITGAL and Syk by the Effects of Cycloastragenol in OVA-Induced Asthmatic Mice. Oxidative Medicine and Cellular Longevity, 2022.

Li, R., Wu, X., Xue, K., & Li, J. (2022). ITGAL infers adverse prognosis and correlates with immunity in acute myeloid leukemia. Cancer Cell International, 22(1), 1-11.

Yang, H., Graham, L. C., Reagan, A. M., Grabowska, W. A., Schott, W. H., & Howell, G. R. (2019). Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity. Journal of Neuroinflammation, 16(1), 1-18.

Zhang, J., Teh, M., Kim, J., Eva, M. M., Cayrol, R., Meade, R., ... & Jaubert, J. (2019). A loss-of-function mutation in the integrin alpha l (itgal) gene contributes to susceptibility to salmonella enterica serovar typhimurium infection in collaborative cross strain cc042. Infection and immunity, 88(1), 10-1128.

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For research use only. Not intended for any clinical use.

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