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Mouse anti-ITGA7 Recombinant Antibody (6A11) (CBMAB-1315-LY)


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Summary

Host Animal
Mouse
Specificity
Mouse
Clone
6A11
Antibody Isotype
IgG1
Application
FC, Neutralization

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.0 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
integrin, alpha 7
Introduction
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity.
Entrez Gene ID
16404
UniProt ID
Q61738
Function
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity).
Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
Biological Process
Cell-matrix adhesionManual Assertion Based On ExperimentTAS:ProtInc
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cell shapeIEA:UniProtKB-KW
Skeletal muscle tissue developmentIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI):
A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures.
Topology
Extracellular: 34-1082
Helical: 1083-1103
Cytoplasmic: 1104-1181
PTM
ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes.
A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.
More Infomation

Gwili, N., Jones, S. J., Amri, W. A., Carr, I. M., Harris, S., Hogan, B. V., ... & Hughes, T. A. (2021). Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response. British Journal of Cancer, 125(7), 983-993.

Xia, W., Ni, Z., Zhang, Z., Sang, H., Liu, H., Chen, Z., ... & Lei, X. (2021). Case report: a boy from a consanguineous family diagnosed with congenital muscular dystrophy caused by integrin alpha 7 (ITGA7) mutation. Frontiers in Genetics, 12, 706823.

Guan, Y., Bhandari, A., Xia, E., Kong, L., Zhang, X., & Wang, O. (2020). Downregulating integrin subunit alpha 7 (ITGA7) promotes proliferation, invasion, and migration of papillary thyroid carcinoma cells through regulating epithelial-to-mesenchymal transition. Acta Biochimica et Biophysica Sinica, 52(2), 116-124.

Yang, G., Zhang, T., Ye, J., Yang, J., Chen, C., Cai, S., & Ma, J. (2019). Circ-ITGA7 sponges miR-3187-3p to upregulate ASXL1, suppressing colorectal cancer proliferation. Cancer management and research, 6499-6509.

Liu, J., Zhang, Z., Li, X., Chen, J., Wang, G., Tian, Z., ... & Xia, L. (2018). Forkhead box C1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression. Oncogene, 37(41), 5477-5491.

Li, X., Wang, J., Zhang, C., Lin, C., Zhang, J., Zhang, W., ... & Li, X. (2018). Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7. The Journal of pathology, 246(2), 166-179.

Bhandari, A., Xia, E., Zhou, Y., Guan, Y., Xiang, J., Kong, L., ... & Zhang, X. (2018). ITGA7 functions as a tumor suppressor and regulates migration and invasion in breast cancer. Cancer management and research, 969-976.

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For research use only. Not intended for any clinical use.

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