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Mouse Anti-ITGA6 Recombinant Antibody (4C1) (CBMAB-I1313-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4C1
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Integrin Subunit Alpha 6
Introduction
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human3655
Mouse16403
UniProt ID
HumanP23229
MouseQ61739
Alternative Names
Integrin Subunit Alpha 6
Function
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity).
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).
Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity).
ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).
ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).
Biological Process
Cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-substrate junction assemblyManual Assertion Based On ExperimentTAS:ProtInc
Ectodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Nail developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIGI:MGI
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentISS:UniProtKB
Positive regulation of phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Skin morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane; Cell membrane
Involvement in disease
Epidermolysis bullosa letalis, with pyloric atresia (EB-PA):
An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Topology
Extracellular: 24-1050
Helical: 1051-1076
Cytoplasmic: 1077-1130
PTM
Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p) (PubMed:11359780, PubMed:15023541, PubMed:17303120).
Production of alpha6p enhances prostate cancer cell invasion and migration (PubMed:17303120).
Palmitoylation by DHHC3 enhances stability and cell surface expression.
More Infomation

Bu, J., Guo, R., Xu, X. Z., Luo, Y., & Liu, J. F. (2021). LncRNA SNHG16 promotes epithelial-mesenchymal transition by upregulating ITGA6 through miR-488 inhibition in osteosarcoma. Journal of bone oncology, 27, 100348.

Song, S., Zhang, J., Su, Q., Zhang, W., Jiang, Y., Fan, G., ... & Zhuang, W. (2021). Downregulation of ITGA6 confers to the invasion of multiple myeloma and promotes progression to plasma cell leukaemia. British Journal of Cancer, 124(11), 1843-1853.

Li, M., Wang, Q., Zhang, X., Yan, N., & Li, X. (2020). Exosomal miR-126 blocks the development of non-small cell lung cancer through the inhibition of ITGA6. Cancer Cell International, 20(1), 1-11.

Feng, C., Jin, X., Han, Y., Guo, R., Zou, J., Li, Y., & Wang, Y. (2020). Expression and prognostic analyses of ITGA3, ITGA5, and ITGA6 in head and neck squamous cell carcinoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e926800-1.

Guo, L., Fu, J., Sun, S., Zhu, M., Zhang, L., Niu, H., ... & Wang, S. (2019). MicroRNA‐143‐3p inhibits colorectal cancer metastases by targeting ITGA6 and ASAP3. Cancer science, 110(2), 805-816.

Wu, Y., Tan, X., Liu, P., Yang, Y., Huang, Y., Liu, X., ... & Jin, H. (2019). ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways. Experimental cell research, 379(1), 30-47.

Jin, H., Ying, X., Que, B., Wang, X., Chao, Y., Zhang, H., ... & Ji, W. (2019). N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer. EBioMedicine, 47, 195-207.

Zhu, Y., Wu, Y., Yang, L., Dou, X., Jiang, J., & Wang, L. (2019). Long non‐coding RNA activated by transforming growth factor‐β promotes proliferation and invasion of cervical cancer cells by regulating the miR‐144/ITGA6 axis. Experimental Physiology, 104(6), 837-844.

Jin, Y. P., Hu, Y. P., Wu, X. S., Wu, Y. S., Ye, Y. Y., Li, H. F., ... & Liu, Y. B. (2018). miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma. Cell death & disease, 9(2), 182.

Wang, D., Tang, L., Wu, H., Wang, K., & Gu, D. (2018). MiR‐127‐3p inhibits cell growth and invasiveness by targeting ITGA6 in human osteosarcoma. IUBMB life, 70(5), 411-419.

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For research use only. Not intended for any clinical use.

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