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Rabbit Anti-IMPA1 Recombinant Antibody (BA0149) (CBMAB-0373CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0149
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Human IMPA1 aa 200 to the C-terminus
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inositol Monophosphatase 1
Introduction
The IMPA1 gene encodes inositol monophosphatase-1 (EC 3.1.3.25), an enzyme critical for recovery of the inositol cycle. It is important both for de novo synthesis of inositol and for the recycling of inositol polyphosphates generated upon receptor activation that relay signaling via intracellular second messengers. IMPA1 gene contains at least 9 exons and spans more than 20 kb. In the 3-prime untranslated part of the gene, they observed a G-to-A transition and also 2 short sequences similar to the inositol/cholin-responsive element consensus. They postulated that 2 additional IMPA-like transcripts originate from the human genome, 1 from a position close to IMPA1 itself on chromosome 8 and the other from 18. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
Entrez Gene ID
Human3612
Mouse55980
Rat83523
UniProt ID
HumanP29218
MouseO55023
RatP97697
Alternative Names
IMP; IMPA
Function
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Biological Process
Inositol biosynthetic processIEA:UniProtKB-UniPathway
Inositol metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Inositol phosphate dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Phosphate-containing compound metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Phosphatidylinositol phosphate biosynthetic processIEA:InterPro
Signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Mental retardation, autosomal recessive 59 (MRT59):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT59 transmission pattern is consistent with autosomal recessive inheritance.
More Infomation

Yang, S. Y., Xie, Y. F., Zhang, T. M., Deng, L., Liao, L., Hu, S. Y., ... & Li, D. Q. (2023). Inositol monophosphatase 1 (IMPA1) promotes triple‐negative breast cancer progression through regulating mTOR pathway and EMT process. Cancer Medicine, 12(2), 1602-1615.

Pessoa, A. L. S., Quesada, A. A., Nóbrega, P. R., Viana, A. P. O., de Oliveira, K. T., Figueiredo, T., ... & Kok, F. (2023). Neuropsychological Characterization of Autosomal Recessive Intellectual Developmental Disorder 59 Associated with IMPA1 (MRT59). Brain Sciences, 13(7), 1048.

Padinjat, R., Saha, S., & Krishnan, H. (2022). IMPA1 dependent regulation of plasma membrane phosphatidylinositol 4, 5-bisphosphate turnover and calcium signalling by lithium. bioRxiv, 2022-10.

Andreassi, C., Luisier, R., Crerar, H., Darsinou, M., Blokzijl-Franke, S., Lenn, T., ... & Riccio, A. (2021). Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity. Cell Reports, 34(8).

Figueiredo, T., Mendes, A. P., Moreira, D. P., Goulart, E., Oliveira, D., Kobayashi, G. S., ... & Zatz, M. (2021). Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Molecular Psychiatry, 26(7), 3558-3571.

Pillai, R. A., Islam, M. O., Selvam, P., Sharma, N., Chu, A. H., Watkins, O. C., ... & Chan, S. Y. (2021). Placental inositol reduced in gestational diabetes as glucose alters inositol transporters and IMPA1 enzyme expression. The Journal of Clinical Endocrinology & Metabolism, 106(2), e875-e890.

Bogatikov, E., Lindblad, I., Punga, T., & Punga, A. R. (2020). miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27. Neuroscience research, 151, 46-52.

Walker, C. P., Pessoa, A. L., Figueiredo, T., Rafferty, M., Melo, U. S., Nóbrega, P. R., ... & Cho, R. Y. (2019). Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG. Orphanet Journal of Rare Diseases, 14(1), 1-10.

Rosette, C., & Murray PhD, M. (2018). P-29 Preparing to Test the Effects of Omega-3 Fatty Acids on Inositol Levels and ISYNA & IMPA1 Gene Expression in Mammalian Cells.

de Farias, A. A., Nunes, K., Lemes, R. B., Moura, R., Fernandes, G. R., Melo, U. S., ... & Santos, S. (2018). Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations. Scientific reports, 8(1), 16552.

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For research use only. Not intended for any clinical use.

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