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Mouse Anti-IL2RA Recombinant Antibody (3H1147) (CBMAB-C1153-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3H1147
Antibody Isotype
IgG1
Application
FC, IP, WB

Basic Information

Immunogen
Human PHA blasts, day 3 of culture
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 2 Receptor Subunit Alpha
Introduction
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Entrez Gene ID
3559
UniProt ID
P01589
Alternative Names
CD25; Il2r; Ly-43
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Biological Process
Activation-induced cell death of T cellsIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of activated T cell proliferationIEA:Ensembl
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of T cell homeostatic proliferationIEA:Ensembl
Regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Involvement in disease
Diabetes mellitus, insulin-dependent, 10 (IDDM10):
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41):
A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
Topology
Extracellular: 22-240
Helical: 241-259
Cytoplasmic: 260-272
More Infomation

Gil-Quiñones, S. R., Sepúlveda-Pachón, I. T., Sánchez Vanegas, G., & Gutierrez-Castañeda, L. D. (2021). Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis. PLoS One, 16(11), e0258499.

Joosse, M. E., Charbit-Henrion, F., Boisgard, R., Lindenbergh-Kortleve, D. J., Costes, L. M., Nugteren, S., ... & Samsom, J. N. (2021). Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis. Mucosal Immunology, 14(5), 1172-1182.

Borysewicz-Sańczyk, H., Sawicka, B., Wawrusiewicz-Kurylonek, N., Głowińska-Olszewska, B., Kadłubiska, A., Gościk, J., ... & Bossowski, A. (2020). Genetic association study of IL2RA, IFIH1, and CTLA-4 polymorphisms with autoimmune thyroid diseases and type 1 diabetes. Frontiers in pediatrics, 8, 481.

Nguyen, C. H., Schlerka, A., Grandits, A. M., Koller, E., van der Kouwe, E., Vassiliou, G. S., ... & Wieser, R. (2020). IL2RA promotes aggressiveness and stem cell–related properties of acute myeloid Leukemia. Cancer research, 80(20), 4527-4539.

Du, W., He, J., Zhou, W., Shu, S., Li, J., Liu, W., ... & Hu, D. (2019). High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia. Journal of translational medicine, 17, 1-14.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

de Oyarzabal, E., García-García, L., Rangel-Escareño, C., Ferreyra-Reyes, L., Orozco, L., Herrera, M. T., ... & Torres, M. (2019). Expression of USP18 and IL2RA is increased in individuals receiving latent tuberculosis treatment with isoniazid. Journal of Immunology Research, 2019.

Wang, X. X., & Chen, T. (2018). Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk. Immunological investigations, 47(5), 431-442.

Belot, M. P., Castell, A. L., Le Fur, S., & Bougnères, P. (2018). Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression. Epigenetics, 13(5), 459-472.

Xia, Z. L., Qin, Q. M., & Zhao, Q. Y. (2018). A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis. Neurological Research, 40(12), 1040-1047.

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For research use only. Not intended for any clinical use.

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