Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rat Anti-IL2RA Recombinant Antibody (AG107) (V2LY-0524-LY92)


See all IL2RA antibodies
Online Inquiry

Summary

Host Animal
Rat
Specificity
Mouse
Clone
AG107
Antibody Isotype
IgG1, λ
Application
Blocking, FC, IHC-F, IP, WB

Basic Information

Immunogen
IL-2-dependent cytolytic mouse T-cell clone B6.1
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG1, λ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
< 1.0 EU/mg as determined by the LAL method
Format
Liquid
Buffer
PBS
Preservative
None
Concentration
5 mg/ml
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 2 Receptor Subunit Alpha
Entrez Gene ID
16184
UniProt ID
P01590
Alternative Names
CD25; Il2r; Ly-43
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Biological Process
Activation-induced cell death of T cellsIEA:Ensembl
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Notch signaling pathwayIEA:Ensembl
Positive regulation of activated T cell proliferationIEA:Ensembl
Positive regulation of T cell differentiationIEA:Ensembl
Regulation of T cell homeostatic proliferationIEA:Ensembl
Regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Involvement in disease
Diabetes mellitus, insulin-dependent, 10 (IDDM10):
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41):
A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
Topology
Extracellular: 22-240
Helical: 241-259
Cytoplasmic: 260-272
More Infomation

Gil-Quiñones, S. R., Sepúlveda-Pachón, I. T., Sánchez Vanegas, G., & Gutierrez-Castañeda, L. D. (2021). Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis. PLoS One, 16(11), e0258499.

Joosse, M. E., Charbit-Henrion, F., Boisgard, R., Lindenbergh-Kortleve, D. J., Costes, L. M., Nugteren, S., ... & Samsom, J. N. (2021). Duplication of the IL2RA locus causes excessive IL-2 signaling and may predispose to very early onset colitis. Mucosal Immunology, 14(5), 1172-1182.

Borysewicz-Sańczyk, H., Sawicka, B., Wawrusiewicz-Kurylonek, N., Głowińska-Olszewska, B., Kadłubiska, A., Gościk, J., ... & Bossowski, A. (2020). Genetic association study of IL2RA, IFIH1, and CTLA-4 polymorphisms with autoimmune thyroid diseases and type 1 diabetes. Frontiers in pediatrics, 8, 481.

Nguyen, C. H., Schlerka, A., Grandits, A. M., Koller, E., van der Kouwe, E., Vassiliou, G. S., ... & Wieser, R. (2020). IL2RA promotes aggressiveness and stem cell–related properties of acute myeloid Leukemia. Cancer research, 80(20), 4527-4539.

Du, W., He, J., Zhou, W., Shu, S., Li, J., Liu, W., ... & Hu, D. (2019). High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia. Journal of translational medicine, 17, 1-14.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

de Oyarzabal, E., García-García, L., Rangel-Escareño, C., Ferreyra-Reyes, L., Orozco, L., Herrera, M. T., ... & Torres, M. (2019). Expression of USP18 and IL2RA is increased in individuals receiving latent tuberculosis treatment with isoniazid. Journal of Immunology Research, 2019.

Wang, X. X., & Chen, T. (2018). Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk. Immunological investigations, 47(5), 431-442.

Belot, M. P., Castell, A. L., Le Fur, S., & Bougnères, P. (2018). Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression. Epigenetics, 13(5), 459-472.

Xia, Z. L., Qin, Q. M., & Zhao, Q. Y. (2018). A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis. Neurological Research, 40(12), 1040-1047.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-IL2RA Recombinant Antibody (AG107)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry