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Mouse Anti-ID1 Recombinant Antibody (CBYY-I1545) (CBMAB-I2715-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYY-I1545
Antibody Isotype
IgG2a, κ
Application
WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ID1
Introduction
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human3397
Mouse15901
UniProt ID
HumanP41134
MouseP20067
Alternative Names
Inhibitor Of DNA Binding 1, HLH Protein
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Biological Process
Angiogenesis Source: BHF-UCL
Blood vessel endothelial cell migration Source: BHF-UCL
Blood vessel morphogenesis Source: BHF-UCL
Brain development Source: Ensembl
Cell-abiotic substrate adhesion Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to dopamine Source: Ensembl
Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to peptide Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Negative regulation of dendrite morphogenesis Source: Ensembl
Negative regulation of DNA binding Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: ARUK-UCL
Negative regulation of endothelial cell differentiation Source: Ensembl
Negative regulation of protein binding Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Neuron differentiation Source: Ensembl
Positive regulation of actin filament bundle assembly Source: Ensembl
Positive regulation of epithelial cell proliferation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Regulation of vasculature development Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Cellular Location
Cytoplasm; Nucleus
More Infomation

Lin, Z., Liu, Y., Xu, T., Su, T., Yang, Y., Liang, R., ... & Xie, L. (2023). STAT3-Mediated Promoter-Enhancer Interaction Up-Regulates Inhibitor of DNA Binding 1 (ID1) to Promote Colon Cancer Progression. International Journal of Molecular Sciences, 24(12), 10041.

Wei, J., Shi, Y., Zou, C., Zhang, H., Peng, H., Wang, S., ... & Wang, D. (2022). Cellular Id1 inhibits hepatitis B virus transcription by interacting with the novel covalently closed circular DNA-binding protein E2F4. International Journal of Biological Sciences, 18(1), 65.

Zuniga, O., Byrum, S., & Wolfe, A. R. (2022). Discovery of the inhibitor of DNA binding 1 as a novel marker for radioresistance in pancreatic cancer using genome-wide RNA-seq. Cancer Drug Resistance, 5(4), 926.

Zhao, Z., Bo, Z., Gong, W., & Guo, Y. (2020). Inhibitor of differentiation 1 (Id1) in cancer and cancer therapy. International journal of medical sciences, 17(8), 995.

Leng, X., Ji, X., Hou, Y., Settlage, R., & Jiang, H. (2019). Roles of the proteasome and inhibitor of DNA binding 1 protein in myoblast differentiation. The FASEB Journal, 33(6), 7403-7416.

Sun, Y., Lai, X., Yu, Y., Li, J., Cao, L., Lin, W., ... & Ye, Y. (2019). Inhibitor of DNA binding 1 (Id1) mediates stemness of colorectal cancer cells through the Id1-c-Myc-PLAC8 axis via the Wnt/β-catenin and Shh signaling pathways. Cancer management and research, 6855-6869.

Ohara, R. A., Edhayan, G., Rasmussen, S. M., Isozaki, T., Remmer, H. A., Lanigan, T. M., ... & Ruth, J. H. (2019). Citrullinated inhibitor of DNA binding 1 is a novel autoantigen in rheumatoid arthritis. Arthritis & Rheumatology, 71(8), 1241-1251.

Zhou, X. L., Zeng, D. E., Ye, Y. H., Sun, S. M., Lu, X. F., Liang, W. Q., ... & Lin, H. Y. (2018). Prognostic values of the inhibitor of DNA‑binding family members in breast cancer. Oncology Reports, 40(4), 1897-1906.

Han, J., Seo, H., Choi, Y., Lee, C., Kim, M. I., Jeon, Y., ... & Ka, H. (2018). Expression and regulation of inhibitor of DNA binding proteins ID1, ID2, ID3, and ID4 at the maternal-conceptus interface in pigs. Theriogenology, 108, 46-55.

Ke, J., Wu, R., Chen, Y., & Abba, M. L. (2018). Inhibitor of DNA binding proteins: implications in human cancer progression and metastasis. American Journal of Translational Research, 10(12), 3887.

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For research use only. Not intended for any clinical use.

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