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Rat Anti-ICOSLG Recombinant Antibody (AG90) (V2LY-0524-LY95)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
AG90
Antibody Isotype
IgG2a
Application
Blocking, FC, In Vivo

Basic Information

Immunogen
Transfected Cell Line for Mouse B7H2
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
< 1.0 EU/mg as determined by the LAL method
Format
Liquid
Buffer
PBS
Preservative
None
Concentration
5 mg/ml
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inducible T Cell Costimulator Ligand
Entrez Gene ID
50723
UniProt ID
Q9JHJ8
Alternative Names
B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; KIAA0653; LICOS
Function
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
B cell activation Source: UniProtKB-KW
Defense response Source: UniProtKB
Hyperosmotic response Source: UniProtKB
Positive regulation of activated T cell proliferation Source: UniProtKB
Regulation of cytokine production Source: GO_Central
Signal transduction Source: UniProtKB
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 19-256
Helical: 257-277
Cytoplasmic: 278-302
More Infomation

Zhang, Y., Wang, X. L., Liu, J. J., Qian, Z. Y., Pan, Z. Y., Song, N. P., ... & Zhang, X. (2023). ICOS/ICOSLG and PD-1 Co-Expression is Associated with the Progression of Colorectal Precancerous-Carcinoma Immune Microenvironment. Journal of Inflammation Research, 977-992.

Külp, M., Siemund, A. L., Larghero, P., Dietz, A., Alten, J., Cario, G., ... & Marschalek, R. (2022). The immune checkpoint ICOSLG is a relapse-predicting biomarker and therapeutic target in infant t (4; 11) acute lymphoblastic leukemia. Iscience, 25(7).

Zhang, C., Wang, F., Sun, N., Zhang, Z., Zhang, G., Zhang, Z., ... & He, J. (2022). The combination of novel immune checkpoints HHLA2 and ICOSLG: A new system to predict survival and immune features in esophageal squamous cell carcinoma. Genes & diseases, 9(2), 415-428.

Külp, M., Larghero, P., Dietz, A., Cario, G., Eckert, C., Caye-Eude, A., ... & Marschalek, R. (2022). The immune checkpoint ICOSLG is a relapse-predicting biomarker and therapeutic target in infant t (4; 11) ALL. Klinische Pädiatrie, 234(03), 174-175.

Roussel, L., & Vinh, D. C. (2021). ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency. Current Opinion in Immunology, 72, 21-26.

Holst, C. B., Christensen, I. J., Vitting-Seerup, K., Skjøth-Rasmussen, J., Hamerlik, P., Poulsen, H. S., & Johansen, J. S. (2021). Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma. Neuro-Oncology Advances, 3(1), vdab072.

Külp, M., Siemund, A. L., Meyer, C., Larghero, P., Dietz, A., Alten, J., ... & Marschalek, R. (2021). Implication of ICOSLG on Relapse in Infant T (4; 11) Acute Lymphoblastic Leukemia. Blood, 138(Supplement 1), 3481-3481.

Iwata, R., Hyoung Lee, J., Hayashi, M., Dianzani, U., Ofune, K., Maruyama, M., ... & Asai, A. (2020). ICOSLG-mediated regulatory T-cell expansion and IL-10 production promote progression of glioblastoma. Neuro-oncology, 22(3), 333-344.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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