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Mouse Anti-ICAM1 Recombinant Antibody (1H4) (CBMAB-C0549-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H4
Antibody Isotype
IgG2b
Application
IHC-F, ICC/IF, WB, FC, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Intercellular Adhesion Molecule 1
Introduction
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3383
UniProt ID
P05362
Alternative Names
Intercellular Adhesion Molecule 1
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.

(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.

(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Biological Process
Adhesion of symbiont to host Source: BHF-UCL
Cell adhesion Source: BHF-UCL
Cell adhesion mediated by integrin Source: Ensembl
Cellular response to amyloid-beta Source: ARUK-UCL
Cellular response to glucose stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Establishment of endothelial barrier Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Leukocyte cell-cell adhesion Source: BHF-UCL
Leukocyte migration Source: BHF-UCL
Membrane to membrane docking Source: BHF-UCL
Negative regulation of endothelial cell apoptotic process Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Positive regulation of cellular extravasation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Receptor-mediated virion attachment to host cell Source: BHF-UCL
Regulation of leukocyte mediated cytotoxicity Source: BHF-UCL
Regulation of ruffle assembly Source: Ensembl
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: BHF-UCL
T cell antigen processing and presentation Source: Ensembl
T cell extravasation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 28-480
Helical: 481-503
Cytoplasmic: 504-532
PTM
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
More Infomation

Bai, X., Guo, Z. Q., Zhang, Y. P., Fan, Z. Z., Liu, L. J., Liu, L., ... & Dong, Z. Y. (2023). CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy. Nature Communications, 14(1), 1247.

Zhang, Y., Zhang, L., Zheng, S., Li, M., Xu, C., Jia, D., ... & Zhuo, W. (2022). Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis. Gut Microbes, 14(1), 2038852.

Chen, M., Wu, C., Fu, Z., & Liu, S. (2022). ICAM1 promotes bone metastasis via integrin‐mediated TGF‐β/EMT signaling in triple‐negative breast cancer. Cancer Science, 113(11), 3751.

Hsieh, C. Y., Lin, C. C., Huang, Y. W., Chen, J. H., Tsou, Y. A., Chang, L. C., ... & Chang, W. C. (2022). Macrophage secretory IL-1β promotes docetaxel resistance in head and neck squamous carcinoma via SOD2/CAT-ICAM1 signaling. JCI insight, 7(23).

Taftaf, R., Liu, X., Singh, S., Jia, Y., Dashzeveg, N. K., Hoffmann, A. D., ... & Liu, H. (2021). ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer. Nature communications, 12(1), 4867.

Gönen, M. S., Alaylıoğlu, M., Durcan, E., Özdemir, Y., Şahin, S., Konukoğlu, D., ... & Dursun, E. (2021). Rapid and effective vitamin D supplementation may present better clinical outcomes in COVID-19 (SARS-CoV-2) patients by altering serum INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Nutrients, 13(11), 4047.

Chen, X., Zhang, X., Su, C., & Huang, S. (2020). Long noncoding RNA HULC in acute ischemic stroke: Association with disease risk, severity, and recurrence‐free survival and relation with IL‐6, ICAM1, miR‐9, and miR‐195. Journal of clinical laboratory analysis, 34(11), e23500.

Lin, J. C., Tsai, J. T., Chao, T. Y., Ma, H. I., & Liu, W. H. (2019). Musashi-1 enhances glioblastoma migration by promoting ICAM1 translation. Neoplasia, 21(5), 459-468.

Zhang, Y., Willis-Owen, S. A., Spiegel, S., Lloyd, C. M., Moffatt, M. F., & Cookson, W. O. (2019). The ORMDL3 asthma gene regulates ICAM1 and has multiple effects on cellular inflammation. American journal of respiratory and critical care medicine, 199(4), 478-488.

Figenschau, S. L., Knutsen, E., Urbarova, I., Fenton, C., Elston, B., Perander, M., ... & Fenton, K. A. (2018). ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes. Scientific reports, 8(1), 11720.

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For research use only. Not intended for any clinical use.

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