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Mouse Anti-IAV H5N1 HA Recombinant Antibody (CBMW-H1311) (CBMAB-V208-1501-FY)


See all IAV H5N1 HA antibodies
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Summary

Host Animal
Mouse
Specificity
Influenza A Virus
Clone
CBMW-H1311
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Synthetic peptide corresponding to 14 amino acids in the middle of the Hemagglutinin protein (Genbank accession no. AAT76166)
Specificity
Influenza A Virus
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Influenza A Virus H5N1 Haemagglutinin
Introduction
Avian influenza—known informally as avian flu or bird flu is a variety of influenza caused by viruses adapted to birds.
Alternative Names
IAV H5N1 HA; Avian Influenza A Virus H5N1 hemagglutinin
Function
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Biological Process
Clathrin-dependent endocytosis of virus by host cell Source: UniProtKB-UniRule
Fusion of virus membrane with host endosome membrane Source: UniProtKB-UniRule
Fusion of virus membrane with host plasma membrane Source: InterPro
Viral budding from plasma membrane Source: UniProtKB-UniRule
Virion attachment to host cell Source: UniProtKB-KW
Cellular Location
Virion membrane; Host apical cell membrane. Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Topology
Extracellular: 17-531
Helical: 532-552
Cytoplasmic: 553-568
PTM
Palmitoylated.
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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