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Mouse Anti-HYAL1 (AA 60-159) Recombinant Antibody (CBFYH-2561) (CBMAB-H3582-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2561
Antibody Isotype
IgG2a, κ
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: ANPGQTFRGP DMTIFYSSQL GTYPYYTPTG EPVFGGLPQN ASLIAHLART FQDILAAIPA PDFSGLAVID WEAWRPRWAF NWDTKDIYRQ RSRALVQAQH
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 60-159

Target

Full Name
hyaluronoglucosaminidase 1
Introduction
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
3373
UniProt ID
Q12794
Alternative Names
Hyaluronoglucosaminidase 1; Lung Carcinoma Protein 1; EC 3.2.1.35; HYAL-1; LuCa-1; LUCA1; Hyaluronoglucosaminidase-1
Function
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Biological Process
Carbohydrate metabolic process Source: InterPro
Cartilage development Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to pH Source: UniProtKB
Cellular response to platelet-derived growth factor stimulus Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Cellular response to UV-B Source: UniProtKB
Chondroitin sulfate catabolic process Source: Reactome
Embryonic skeletal joint morphogenesis Source: Ensembl
Hyaluronan biosynthetic process Source: UniProtKB
Hyaluronan catabolic process Source: UniProtKB
Hyaluronan metabolic process Source: UniProtKB
Inflammatory response Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of epithelial cell proliferation Source: UniProtKB
Positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Positive regulation of growth Source: UniProtKB
Positive regulation of hyaluranon cable assembly Source: UniProtKB
Response to antibiotic Source: UniProtKB
Response to reactive oxygen species Source: UniProtKB
Response to virus Source: UniProtKB
Cellular Location
Lysosome; Secreted
Involvement in disease
Mucopolysaccharidosis 9 (MPS9):
A lysosomal storage disease characterized by high hyaluronan concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
More Infomation

Xing, H., Li, S., Fu, Y., Wan, X., Zhou, A., Cao, F., ... & Cao, C. (2023). HYAL1 deficiency attenuates lipopolysaccharide-triggered renal injury and endothelial glycocalyx breakdown in septic AKI in mice. Renal Failure, 45(1), 2188966.

Riecks, J., Parnigoni, A., Győrffy, B., Kiesel, L., Passi, A., Vigetti, D., & Götte, M. (2022). The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer. Journal of Cancer Research and Clinical Oncology, 148(12), 3399-3419.

Leng, D., Huang, X., Yi, J., Zhao, H., & Zhang, Y. (2020). HYAL1 is downregulated in idiopathic pulmonary fibrosis and inhibits HFL-1 fibroblast proliferation when upregulated. BioMed research international, 2020, 1-15.

Lengers, I., Herrmann, F., Le Borgne, M., & Jose, J. (2020). Improved surface display of human Hyal1 and identification of testosterone propionate and chicoric acid as new inhibitors. Pharmaceuticals, 13(4), 54.

Duan, H., Donovan, M., Hernandez, F., Di Primo, C., Garanger, E., Schultze, X., & Lecommandoux, S. (2020). Hyaluronic‐Acid‐Presenting Self‐Assembled Nanoparticles Transform a Hyaluronidase HYAL1 Substrate into an Efficient and Selective Inhibitor. Angewandte Chemie International Edition, 59(32), 13591-13596.

Krupkova, O., Greutert, H., Boos, N., Lemcke, J., Liebscher, T., & Wuertz-Kozak, K. (2020). Expression and activity of hyaluronidases HYAL-1, HYAL-2 and HYAL-3 in the human intervertebral disc. European Spine Journal, 29, 605-615.

McAtee, C. O., Booth, C., Elowsky, C., Zhao, L., Payne, J., Fangman, T., ... & Simpson, M. A. (2019). Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling. Matrix Biology, 78, 165-179.

Jin, Z., Zhang, G., Liu, Y., He, Y., Yang, C., Du, Y., & Gao, F. (2019). The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer. Journal of Gastroenterology and Hepatology, 34(10), 1766-1776.

Addotey, J. N., Lengers, I., Jose, J., & Hensel, A. (2019). Hyal-1 inhibitors from the leaves of Phyllanthus muellerianus (Kuntze) Excell. Journal of ethnopharmacology, 236, 326-335.

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For research use only. Not intended for any clinical use.

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