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Mouse Anti-HSF2 Recombinant Antibody (1F11-A3) (CBMAB-A4106-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F11-A3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HSF2 (AAH05329, 1 a.a. ~ 230 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
heat shock transcription factor 2
Introduction
HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors. [provided by RefSeq]
Entrez Gene ID
3298
UniProt ID
Q03933
Alternative Names
MGC117376; MGC156196; MGC75048
Function
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Biological Process
Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: Ensembl
Cellular Location
Nucleus; Cytoplasm. Cytoplasmic during normal growth and moves to the nucleus upon activation.
More Infomation

Tokunaga, Y., Otsuyama, K. I., Kakuta, S., & Hayashida, N. (2022). Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases. International Journal of Molecular Sciences, 23(22), 13763.

Vijayavittal, A. K., Kumar, P., Sugunan, S., Joseph, C., Devaki, B., Paithankar, K., & Subbarao, S. A. (2022). Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis. Biochemical and Biophysical Research Communications, 600, 44-50.

Liang, H., Zhang, F., Wang, W., Zhao, W., Zhou, J., Feng, Y., ... & Miao, Y. (2022). Heat shock transcription factor 2 promotes mitophagy of intestinal epithelial cells through PARL/PINK1/Parkin pathway in ulcerative colitis. Frontiers in Pharmacology, 13, 893426.

Zhang, F., Zhao, W., Zhou, J., Wang, W., Luo, J., Feng, Y., ... & Miao, Y. (2021). Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting NLRP3 inflammasome activation in ulcerative colitis. Gene, 768, 145299.

Drissi, I., Deschamps, C., Alary, R., Robert, A., Dubreuil, V., Le Mouël, A., ... & Pierrefiche, O. (2021). Role of heat shock transcription factor 2 in the NMDA‐dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. Addiction Biology, 26(2), e12939.

Wang, W., Zhang, F., Li, X., Luo, J., Sun, Y., Wu, J., ... & Miao, Y. (2020). Heat shock transcription factor 2 inhibits intestinal epithelial cell apoptosis through the mitochondrial pathway in ulcerative colitis. Biochemical and Biophysical Research Communications, 527(1), 173-179.

Zhang, F., Wang, W., Niu, J., Yang, G., Luo, J., Lan, D., ... & Miao, Y. (2020). Heat-shock transcription factor 2 promotes sodium butyrate-induced autophagy by inhibiting mTOR in ulcerative colitis. Experimental cell research, 388(1), 111820.

Joutsen, J., Da Silva, A. J., Luoto, J. C., Budzynski, M. A., Nylund, A. S., de Thonel, A., ... & Sistonen, L. (2020). Heat shock factor 2 protects against proteotoxicity by maintaining cell-cell adhesion. Cell Reports, 30(2), 583-597.

Wen, Y., Niu, J., Zhang, F., Wu, J., Li, M., Sun, Y., ... & Miao, Y. (2020). Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis. Scandinavian Journal of Gastroenterology, 55(6), 677-686.

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For research use only. Not intended for any clinical use.

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