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Mouse Anti-HPV16 E7 Recombinant Antibody (A272) (CBMAB-AP3176LY)


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Summary

Host Animal
Mouse
Specificity
Human papilloma virus
Clone
A272
Antibody Isotype
IgG2a
Application
ELISA, FC, IF, WB

Basic Information

Immunogen
HPV 16 E7 synthesised from S. pombe
Specificity
Human papilloma virus
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Human Papilloma virus type 16 early protein E7
Function
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Biological Process
Modulation by virus of host G1/S transition checkpoint Source: UniProtKB-UniRule
Modulation by virus of host transcription Source: UniProtKB
Positive regulation by symbiont of host transcription Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity Source: UniProtKB
Suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule
Cellular Location
Host cytoplasm; Host nucleus. Predominantly found in the host nucleus.
PTM
Highly phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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