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Mouse Anti-HOXB7 Monoclonal Antibody (CBFYH-3192) (CBMAB-H2782-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3192
Antibody Isotype
IgG1
Application
WB, Dot

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Homeobox B7
Introduction
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.
Entrez Gene ID
3217
UniProt ID
P09629
Alternative Names
Homeobox B7; Homeobox Protein HHO.C1; Homeobox Protein Hox-2C; Homeo Box B7; HOX2C; Homeobox Protein Hox-B7
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Embryonic organ development Source: UniProtKB
Embryonic skeletal system morphogenesis Source: Ensembl
Myeloid cell differentiation Source: Ensembl
Positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
More Infomation

Komatsuda, H., Wakisaka, R., Kono, M., Kumai, T., Hayashi, R., Yamaki, H., ... & Kobayashi, H. (2023). Mitogen‐activated protein kinase inhibition augments the T cell response against HOXB7‐expressing tumor through human leukocyte antigen upregulation. Cancer Science, 114(2), 399.

de Bessa Garcia, S. A., Araújo, M., Pereira, T., & Freitas, R. (2021). HOXB7 overexpression leads triple-negative breast Cancer cells to a less aggressive phenotype. Biomedicines, 9(5), 515.

Casari, G., Resca, E., Giorgini, A., Candini, O., Petrachi, T., Piccinno, M. S., ... & Veronesi, E. (2021). Microfragmented adipose tissue is associated with improved ex vivo performance linked to HOXB7 and b-FGF expression. Stem Cell Research & Therapy, 12(1), 1-13.

Zhou, T., Fu, H., Dong, B., Dai, L., Yang, Y., Yan, W., & Shen, L. (2020). HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair. Thoracic Cancer, 11(11), 3071-3085.

Cheng, W., Shi, X., Lin, M., Yao, Q., Ma, J., & Li, J. (2020). LncRNA MAGI2-AS3 overexpression sensitizes esophageal cancer cells to irradiation through down-regulation of HOXB7 via EZH2. Frontiers in Cell and Developmental Biology, 8, 552822.

Zhang, D. W., Wu, H. Y., Zhu, C. R., & Wu, D. D. (2020). CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma. International Journal of Oncology, 57(2), 478-487.

Dai, L., Hu, W., Yang, Z., Chen, D., He, B., Chen, Y., ... & Zheng, S. (2019). Upregulated expression of HOXB7 in intrahepatic cholangiocarcinoma is associated with tumor cell metastasis and poor prognosis. Laboratory Investigation, 99(6), 736-748.

Foppiani, E. M., Candini, O., Mastrolia, I., Murgia, A., Grisendi, G., Samarelli, A. V., ... & Dominici, M. (2019). Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors. Stem Cell Research & Therapy, 10(1), 1-12.

Monterisi, S., Lo Riso, P., Russo, K., Bertalot, G., Vecchi, M., Testa, G., ... & Bianchi, F. (2018). HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene, 37(26), 3575-3588.

Gao, D., & Chen, H. Q. (2018). Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/β-catenin signaling pathway. American Journal of Physiology-Cell Physiology, 315(5), C675-C686.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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