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Mouse Anti-HLF Recombinant Antibody (2C9) (CBMAB-A3948-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2C9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HLF (AAH36093, 1 a.a. ~ 295 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
hepatic leukemia factor
Introduction
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
Entrez Gene ID
3131
UniProt ID
Q16534
Alternative Names
MGC33822
Biological Process
Multicellular organism development Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Rhythmic process Source: UniProtKB-KW
Skeletal muscle cell differentiation Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.
More Infomation

Li, M., Yao, T., Lin, W., Hinckley, W. E., Galli, M., Muchero, W., ... & Huang, S. S. C. (2023). Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors. Nature communications, 14(1), 2600.

Yang, Y., Yu, T. F., Ma, J., Chen, J., Zhou, Y. B., Chen, M., ... & Xu, Z. S. (2020). The soybean bZIP transcription factor gene GmbZIP2 confers drought and salt resistances in transgenic plants. International journal of molecular sciences, 21(2), 670.

Rambousek, L., Gschwind, T., Lafourcade, C., Paterna, J. C., Dib, L., Fritschy, J. M., & Fontana, A. (2020). Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor. Scientific reports, 10(1), 3760.

Chen, J., Liu, A., Lin, Z., Wang, B., Chai, X., Chen, S., ... & Huang, Y. (2020). Downregulation of the circadian rhythm regulator HLF promotes multiple-organ distant metastases in non-small cell lung cancer through PPAR/NF-κb signaling. Cancer Letters, 482, 56-71.

Michael, R., Ranjan, A., Kumar, R. S., Pathak, P. K., & Trivedi, P. K. (2020). Light-regulated expression of terpene synthase gene, AtTPS03, is controlled by the bZIP transcription factor, HY5, in Arabidopsis thaliana. Biochemical and Biophysical Research Communications, 529(2), 437-443.

Xiang, D. M., Sun, W., Ning, B. F., Zhou, T. F., Li, X. F., Zhong, W., ... & Ding, J. (2018). The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis. Gut, 67(9), 1704-1715.

Suzuki, K., Yoshida, K., Ueha, T., Kaneshiro, K., Nakai, A., Hashimoto, N., ... & Hashiramoto, A. (2018). Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts. Arthritis Research & Therapy, 20, 1-10.

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For research use only. Not intended for any clinical use.

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