Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-HLA-DQA1 Recombinant Antibody (Tu169) (CBMAB-H0330-FY)


See all HLA-DQA1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
Tu169
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
major histocompatibility complex, class II, DQ alpha 1
Introduction
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
Entrez Gene ID
3117
UniProt ID
P01909
Alternative Names
Major Histocompatibility Complex, Class II, DQ Alpha 1; MHC Class II DQA1; DC-1 Alpha Chain; DC-Alpha; HLA-DCA; HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Cellular Location
Lysosome membrane; Endosome membrane
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-HLA-DQA1 Recombinant Antibody (Tu169)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry