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Mouse Anti-HIP1R Recombinant Antibody (CBFYH-1121) (CBMAB-H2074-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1121
Antibody Isotype
IgG1, κ
Application
ELISA, ELISA(Cap), WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
huntingtin interacting protein 1 related
Introduction
HIP1R (Huntingtin Interacting Protein 1 Related) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include actin binding and phosphatidylinositol binding. An important paralog of this gene is HIP1.
Entrez Gene ID
9026
UniProt ID
O75146
Alternative Names
Huntingtin Interacting Protein 1 Related; HIP1-Related Protein; HIP-12; HIP12; Huntingtin-Interacting Protein 1-Related Protein; Huntingtin Interacting Protein 12
Function
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Biological Process
Actin filament organization Source: GO_Central
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
Apoptotic process Source: InterPro
Clathrin coat assembly Source: GO_Central
Digestive system development Source: Ensembl
Endocytosis Source: GO_Central
Negative regulation of actin filament polymerization Source: ParkinsonsUK-UCL
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: Ensembl
Positive regulation of apoptotic process Source: ParkinsonsUK-UCL
Positive regulation of clathrin coat assembly Source: Ensembl
Positive regulation of epidermal growth factor receptor signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of platelet-derived growth factor receptor-beta signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of protein binding Source: ParkinsonsUK-UCL
Protein stabilization Source: ParkinsonsUK-UCL
Receptor-mediated endocytosis Source: UniProtKB
Regulation of actin cytoskeleton organization Source: ParkinsonsUK-UCL
Regulation of clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
Regulation of endocytosis Source: ParkinsonsUK-UCL
Regulation of gastric acid secretion Source: Ensembl
Cellular Location
Perinuclear region; Endomembrane system; Clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
More Infomation

Zhu, S., Xu, H., Chen, R., Shen, Q., Yang, D., Peng, H., ... & Fu, Q. (2023). DNA methylation and miR‐92a‐3p‐mediated repression of HIP1R promotes pancreatic cancer progression by activating the PI3K/AKT pathway. Journal of Cellular and Molecular Medicine, 27(6), 788-802.

Felix, M., Friedel, D., Jayavelu, A. K., Filipski, K., Reinhardt, A., Warnken, U., ... & Reuss, D. E. (2022). HIP1R and vimentin immunohistochemistry predict 1p/19q status in IDH-mutant glioma. Neuro-oncology, 24(12), 2121-2132.

Yang, N., Liang, Y., Yang, P., & Jiang, L. (2022). Flurbiprofen inhibits cell proliferation in thyroid cancer through interrupting HIP1R-induced endocytosis of PTEN. European Journal of Medical Research, 27(1), 1-10.

Pashkova, N., Gakhar, L., Yu, L., Schnicker, N. J., Minard, A. Y., Winistorfer, S., ... & Piper, R. C. (2021). ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals. Elife, 10, e72583.

Zhu, J., Wang, X., Guan, H., Xiao, Q., Wu, Z., Shi, J., ... & Wang, Z. (2020). HIP1R acts as a tumor suppressor in gastric cancer by promoting cancer cell apoptosis and inhibiting migration and invasion through modulating Akt. Journal of Clinical Laboratory Analysis, 34(9), e23425.

Koh, Y. W., Han, J. H., Haam, S., & Lee, H. W. (2020). HIP1R expression and its association with PD-1 pathway blockade response in refractory advanced nonsmall cell lung cancer: a gene set enrichment analysis. Journal of Clinical Medicine, 9(5), 1425.

Wang, H., Yao, H., Li, C., Shi, H., Lan, J., Li, Z., ... & Xu, J. (2019). HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity. Nature chemical biology, 15(1), 42-50.

Qu, Z., & D’Mello, S. R. (2018). Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration. Experimental Biology and Medicine, 243(7), 627-638.

Yang, Q., Peng, L., Wu, Y., Li, Y., Wang, L., Luo, J. H., & Xu, J. (2018). Endocytic adaptor protein HIP1R controls intracellular trafficking of epidermal growth factor receptor in neuronal dendritic development. Frontiers in Molecular Neuroscience, 11, 447.

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For research use only. Not intended for any clinical use.

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