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Rabbit Anti-HGS Recombinant Antibody (CBFYH-1047) (CBMAB-H1990-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Cattle, Dog
Clone
CBFYH-1047
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Monkey, Cattle, Dog
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate
Introduction
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
Entrez Gene ID
Human9146
Mouse15239
Cattle511582
Monkey714385
Dog483367
UniProt ID
HumanO14964
MouseQ99LI8
CattleQ0V8S0
MonkeyA0A0D9S4K7
Alternative Names
Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate; Protein Pp110; HRS; Human Growth Factor-Regulated Tyrosine Kinase Substrate
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Biological Process
Endosomal transport Source: UniProtKB
Macroautophagy Source: ParkinsonsUK-UCL
Membrane invagination Source: UniProtKB
Multivesicular body assembly Source: ParkinsonsUK-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of receptor signaling pathway via JAK-STAT Source: HGNC-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of exosomal secretion Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Protein localization to membrane Source: UniProtKB
Protein targeting to lysosome Source: UniProtKB
Regulation of MAP kinase activity Source: UniProtKB
Regulation of protein catabolic process Source: HGNC-UCL
Signal transduction Source: ProtInc
Cellular Location
Early endosome membrane; Multivesicular body membrane; Cytoplasm. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.
PTM
Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.
Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).
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For research use only. Not intended for any clinical use.

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