Mouse Anti-HES4 Recombinant Antibody (CBFYH-0961) (CBMAB-H1901-FY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-0961

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Hes Family Bhlh Transcription Factor 4

Introduction

HES4 (Hes Family BHLH Transcription Factor 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protein dimerization activity. An important paralog of this gene is HES1.

Entrez Gene ID

57801

UniProt ID

Q9HCC6

Alternative Names

Hes Family BHLH Transcription Factor 4; Class B Basic Helix-Loop-Helix Protein 42; Hairy And Enhancer Of Split 4; BHLH Factor Hes4; BHLHb42; HHES4; Hairy And Enhancer Of Split 4 (Drosophila); Transcription Factor HES-4

Function

Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Cell differentiation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

De Decker, M., Lavaert, M., Roels, J., Tilleman, L., Vandekerckhove, B., Leclercq, G., ... & Taghon, T. (2021). HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development. Haematologica, 106(1), 130.

Santiago-Algarra, D., Souaid, C., Singh, H., Dao, L. T., Hussain, S., Medina-Rivera, A., ... & Spicuglia, S. (2021). Epromoters function as a hub to recruit key transcription factors required for the inflammatory response. Nature communications, 12(1), 6660.

Coomer, C. E., Wilson, S. G., Titialii-Torres, K. F., Bills, J. D., Krueger, L. A., Petersen, R. A., ... & Morris, A. C. (2020). Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival. Scientific reports, 10(1), 11316.

Kikuchi, M., Kizaki, K., Shigeno, S., Toji, N., Ishiguro-Oonuma, T., Koshi, K., ... & Hashizume, K. (2019). Newly identified interferon tau-responsive Hes family BHLH transcription factor 4 and cytidine/uridine monophosphate kinase 2 genes in peripheral blood granulocytes during early pregnancy in cows. Domestic animal endocrinology, 68, 64-72.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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