Mouse Anti-HDLBP Recombinant Antibody (CBFYH-3550) (CBMAB-H4102-FY)

Name: Mouse Anti-HDLBP Recombinant Antibody (CBFYH-3550)
SKU: CBMAB-H4102-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-3550

Antibody Isotype

IgG2a

Application

ELISA

Basic Information

Immunogen

Purified human HDL

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

high density lipoprotein (HDL) binding protein

Introduction

The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation.

Entrez Gene ID

3069

UniProt ID

Q00341

Alternative Names

High Density Lipoprotein Binding Protein; HDL-Binding Protein; Vigilin; HBP; VGL; High Density Lipoprotein-Binding Protein; PRO2900

Function

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.

Biological Process

Cholesterol metabolic process Source: ProtInc
Lipid transport Source: UniProtKB-KW

Cellular Location

Nucleus; Cytoplasm

More Infomation

References

Yuan, J., Lv, T., Yang, J., Wu, Z., Yan, L., Yang, J., ... & Jiang, L. (2023). HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. Cellular and Molecular Gastroenterology and Hepatology, 15(2), 307-325.

Yuan, J., Lv, T., Yang, J., Wu, Z., Yan, L., Yang, J., & Shi, Y. (2022). HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma. Redox Biology, 58, 102546.

Zinnall, U., Milek, M., Minia, I., Vieira-Vieira, C. H., Müller, S., Mastrobuoni, G., ... & Landthaler, M. (2022). HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins. Nature Communications, 13(1), 2727.

Yuan, J., Lv, T., Yang, J., Wu, Z., Yan, L., Yang, J., ... & Jiang, L. (2022). The lipid transporter HDLBP promotes hepatocellular carcinoma metastasis through BRAF-dependent epithelial-mesenchymal transition. Cancer Letters, 549, 215921.

Kosmas, K., Filippakis, H., Khabibullin, D., Turkiewicz, M., Lam, H. C., Yu, J., ... & Henske, E. P. (2021). TSC2 interacts with HDLBP/vigilin and regulates stress granule formation. Molecular Cancer Research, 19(8), 1389-1397.

Zinnall, U. (2021). Functional characterization of the RNA-binding protein HDLBP.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-HDLBP Monoclonal Antibody (CBFYH-3047)

Mouse Anti-HDLBP Recombinant Antibody (B-P37)

Mouse Anti-HDLBP Recombinant Antibody (CBFYH-3551)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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