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Mouse Anti-HDAC11 Recombinant Antibody (CBFYH-0829) (CBMAB-H1741-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0829
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human HDAC11 produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Histone Deacetylase 11
Introduction
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
79885
UniProt ID
Q96DB2
Alternative Names
Histone Deacetylase 11; EC 3.5.1.98; HD11
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Biological Process
Chromatin organization Source: UniProtKB
Histone deacetylation Source: UniProtKB
Oligodendrocyte development Source: Ensembl
Cellular Location
Nucleus
More Infomation

Chen, H., Xie, C., Chen, Q., & Zhuang, S. (2022). HDAC11, an emerging therapeutic target for metabolic disorders. Frontiers in Endocrinology, 13, 989305.

Yao, F., Jin, Z., Zheng, Z., Lv, X., Ren, L., Yang, J., ... & Lin, R. (2022). HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells. Cell death discovery, 8(1), 112.

Wen, Y., Zhang, X., Li, X., Tian, L., Shen, S., Ma, J., & Ai, F. (2022). Histone deacetylase (HDAC) 11 inhibits matrix metalloproteinase (MMP) 3 expression to suppress colorectal cancer metastasis. Journal of Cancer, 13(6), 1923.

Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., ... & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research, 81(8), 2015-2028.

Bora-Singhal, N., Mohankumar, D., Saha, B., Colin, C. M., Lee, J. Y., Martin, M. W., ... & Chellappan, S. (2020). Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2. Scientific reports, 10(1), 4722.

Liu, S. S., Wu, F., Jin, Y. M., Chang, W. Q., & Xu, T. M. (2020). HDAC11: a rising star in epigenetics. Biomedicine & pharmacotherapy, 131, 110607.

Wang, W., Ding, B., Lou, W., & Lin, S. (2020). Promoter hypomethylation and miR-145-5p downregulation-mediated HDAC11 overexpression promotes sorafenib resistance and metastasis of hepatocellular carcinoma cells. Frontiers in cell and developmental biology, 8, 724.

Heim, C. E., Bosch, M. E., Yamada, K. J., Aldrich, A. L., Chaudhari, S. S., Klinkebiel, D., ... & Kielian, T. (2020). Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection. Nature microbiology, 5(10), 1271-1284.

Cao, J., Sun, L., Aramsangtienchai, P., Spiegelman, N. A., Zhang, X., Huang, W., ... & Lin, H. (2019). HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proceedings of the National Academy of Sciences, 116(12), 5487-5492.

Yanginlar, C., & Logie, C. (2018). HDAC11 is a regulator of diverse immune functions. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1861(1), 54-59.

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For research use only. Not intended for any clinical use.

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