Rabbit Anti-HAUS6 Recombinant Antibody (CBXF-1090) (CBMAB-F1016-CQ)

See all HAUS6 antibodies

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBXF-1090

Antibody Isotype

IgG

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

HAUS Augmin Like Complex Subunit 6

Introduction

The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Entrez Gene ID

54801

UniProt ID

Q7Z4H7

Alternative Names

HAUS Augmin Like Complex Subunit 6; Family With Sequence Similarity 29, Member A; FAM29A; Dgt6; HAUS Augmin-Like Complex Subunit 6; Dim Gamma-Tubulin Homolog; KIAA1574;

Function

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.

Biological Process

Cell division Source: UniProtKB-KW
Centrosome cycle Source: UniProtKB
Microtubule cytoskeleton organization Source: GO_Central
Spindle assembly Source: UniProtKB

Cellular Location

Cytoskeleton; Spindle; Centrosome. Localizes to interphase centrosomes and to mitotic spindle microtubules.

PTM

Phosphorylated during mitosis.

More Infomation

References

Shen, A., Liu, L., Huang, Y., Shen, Z., Wu, M., Chen, X., ... & Peng, J. (2022). Down-regulating HAUS6 suppresses cell proliferation by activating the p53/p21 pathway in colorectal cancer. Frontiers in Cell and Developmental Biology, 9, 772077.

Shen, A., Liu, L., Huang, Y., Shen, Z., Wu, M., Chen, X., ... & Peng, J. (2020). Targeting Spindle-Associated Protein HAUS6 Prevents Cell Growth of Colorectal Cancer Cells by Activating the P53/P21 Pathway.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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