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Mouse Anti-H2-D1 Recombinant Antibody (CBFYH-3350) (CBMAB-H0424-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBFYH-3350
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
C3H.SW mouse splenocytes1, 2
Specificity
Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Histocompatibility 2, D Region Locus 1
Introduction
The genes at the H-2D region only (B10.BR → B6AF1), at the H-2K region only (B10.D2 → B6AF1), at loci other than H-2 (129 → B/10); and at H-2D, H-2K, and non-H-2 loci (A → (129 X B/10)F1).
Entrez Gene ID
14964
UniProt ID
P01899
Alternative Names
H-2D; H2-D; H2-K1
Function
Involved in the presentation of foreign antigens to the immune system.
Biological Process
Antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
Immune response Source: InterPro
Negative regulation of neuron projection development Source: MGI
Positive regulation of T cell mediated cytotoxicity Source: MGI
Cellular Location
Membrane
Topology
Extracellular: 25-309
Helical: 310-331
Cytoplasmic: 332-362
PTM
Polyubiquitinated in case of infection by murid herpesvirus 4, by the viral E3 ligase K3 (mK3). This modification causes the protein to be targeted for rapid degradation by the endoplasmic reticulum-associated degradation (ERAD) system. Ubiquitination occurs on lysine, as well as serine and threonine residues present in the cytoplasmic tail. Serine and threonine residues are subject to ubiquitination via ester bonds instead of the usual isopeptide linkage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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