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Mouse Anti-GUSB Recombinant Antibody (CBLG1-2152) (CBMAB-G5816-LY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBLG1-2152
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Glucuronidase Beta
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glucuronidase, beta
Introduction
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]
Entrez Gene ID
24434
UniProt ID
P06760
Alternative Names
Ac2-223; Gus-s
Function
Plays an important role in the degradation of dermatan and keratan sulfates.
Biological Process
Carbohydrate metabolic process Source: ProtInc
Glucuronoside catabolic process Source: GO_Central
Glycosaminoglycan catabolic process Source: ProtInc
Cellular Location
Lysosome
Involvement in disease
Mucopolysaccharidosis 7 (MPS7):
An autosomal recessive lysosomal storage disease characterized by inability to degrade glucuronic acid-containing glycosaminoglycans. The phenotype is highly variable, ranging from severe lethal hydrops fetalis to mild forms with survival into adulthood. Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment.
PTM
N-linked glycosylated with 3 to 4 oligosaccharide chains.
More Infomation

Lieu, L. (2023). Characterization of β-glucuronidase for Enzyme Replacement Therapy in DYT6 Dystonia.

Wei, Y., Tan, H., Yang, R., Yang, F., Liu, D., Huang, B., ... & Liang, Y. (2023). Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis. Fertility and Sterility.

Müller, A., Aboutara, N., Jungen, H., Szewczyk, A., Piesch, M., & Iwersen-Bergmann, S. (2022). Formation of ethyl glucuronide by beta-glucuronidase. Toxicologie Analytique et Clinique, 34(3), S71-S72.

Xu, D., & Cui, G. (2022). Glucuronidase beta is an early predictive marker for the use of antidepressant in the treatment of glioma patients. Tropical Journal of Pharmaceutical Research, 21(10), 2261-2268.

Kong, X., Zheng, Z., Song, G., Zhang, Z., Liu, H., Kang, J., ... & Xia, Y. (2022). Over-expression of GUSB leads to primary resistance of Anti-PD1 therapy in hepatocellular carcinoma. Frontiers in Immunology, 13, 876048.

Albert, E., Ferrer, B., Torres, I., Serrano, A., Alcaraz, M. J., Buesa, J., ... & Navarro, D. (2021). Amplification of human β‐glucuronidase gene for appraising the accuracy of negative SARS‐CoV‐2 RT‐PCR results in upper respiratory tract specimens. Journal of Medical Virology, 93(1), 48.

Kunihiro, A. G., Luis, P. B., Brickey, J. A., Frye, J. B., Chow, H. H. S., Schneider, C., & Funk, J. L. (2019). Beta-glucuronidase catalyzes deconjugation and activation of curcumin-glucuronide in bone. Journal of natural products, 82(3), 500-509.

Dubot, P., Sabourdy, F., Plat, G., Jubert, C., Cancès, C., Broué, P., ... & Levade, T. (2019). First report of a patient with MPS type VII, due to novel mutations in GUSB, who underwent enzyme replacement and then hematopoietic stem cell transplantation. International Journal of Molecular Sciences, 20(21), 5345.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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