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Mouse Anti-GUCY1B1 Recombinant Antibody (GC11) (CBMAB-G5780-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
GC11
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Guanylate Cyclase 1 Soluble Subunit Beta 1
Introduction
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Entrez Gene ID
2983
UniProt ID
Q02153
Alternative Names
Guanylate Cyclase 1 Soluble Subunit Beta 1; GUCY1B3; Guanylate Cyclase 1 Soluble Subunit Beta; Guanylate Cyclase Soluble Subunit Beta-3; Soluble Guanylate Cyclase Small Subunit; Guanylate Cyclase 1; Soluble; Beta 3; GCS-Beta-1; GCS-Beta-3;
Function
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
Biological Process
Blood circulation Source: ProtInc
Cellular response to nitric oxide Source: UniProtKB
cGMP biosynthetic process Source: UniProtKB
cGMP-mediated signaling Source: GO_Central
Nitric oxide-cGMP-mediated signaling pathway Source: UniProtKB
Nitric oxide mediated signal transduction Source: ProtInc
Trans-synaptic signaling by nitric oxide, modulating synaptic transmission Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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