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Mouse Anti-GTF2H2 Antibody (1B9) (CBMAB-0428-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B9
Antibody Isotype
IgG1
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
GTF2H2
Introduction
GTF2H2 (general transcription factor IIH subunit 2) is the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. GTF2H2 is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. A second copy of this gene within the centromeric copy of the duplication has been described in the literature.
Entrez Gene ID
2966
UniProt ID
Q13888
Alternative Names
BTF2; BTF2P44; p44; T-BTF2P44; TFIIH
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
Biological Process
G protein-coupled receptor internalization Source: UniProtKB
Nucleotide-excision repair Source: GO_Central
Positive regulation of DNA helicase activity Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to UV Source: ProtInc
Transcription by RNA polymerase II Source: UniProtKB
Transcription initiation from RNA polymerase II promoter Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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