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Mouse Anti-GSTM3 Recombinant Antibody (CBLG1-2038) (CBMAB-G5519-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2038
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Glutathione S Transferase Mu 3, Brain
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GSTM3
Introduction
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Entrez Gene ID
2947
UniProt ID
P21266
Alternative Names
Glutathione S-Transferase Mu 3; Glutathione S-Transferase Mu 3 (Brain); Glutathione S-Transferase M3 (Brain); GST Class-Mu 3; EC 2.5.1.18; HGSTM3-3; GSTM3-3; GST5; Brain Type Mu-Glutathione S-Transferase;
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
Biological Process
Cellular detoxification of nitrogen compound Source: BHF-UCL
Establishment of blood-nerve barrier Source: ProtInc
Glutathione metabolic process Source: UniProtKB
Nitrobenzene metabolic process Source: BHF-UCL
Response to estrogen Source: UniProtKB
Xenobiotic catabolic process Source: BHF-UCL
Cellular Location
Cytoplasm
PTM
The N-terminus is blocked.
More Infomation

Chen, T., Jinlin, D., Wang, F., Yuan, Z., Xue, J., Lu, T., ... & Zhang, Y. (2022). GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling. Cancer Letters, 538, 215692.

Llavanera, M., Delgado-Bermúdez, A., Mateo-Otero, Y., Padilla, L., Romeu, X., Roca, J., ... & Yeste, M. (2020). Exploring seminal plasma GSTM3 as a quality and in vivo fertility biomarker in pigs—relationship with sperm morphology. Antioxidants, 9(8), 741.

Juang, J. M. J., Binda, A., Lee, S. J., Hwang, J. J., Chen, W. J., Liu, Y. B., ... & Antzelevitch, C. (2020). GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death. EBioMedicine, 57, 102843.

Wang, S., Yang, J., You, L., Dai, M., & Zhao, Y. (2020). GSTM3 function and polymorphism in cancer: emerging but promising. Cancer management and research, 12, 10377.

Moghimi, M., Sobhan, M. R., Jarahzadeh, M. H., Morovati-Sharifabad, M., Aghili, K., Ahrar, H., ... & Neamatzadeh, H. (2019). Association of GSTM1, GSTT1, GSTM3, and GSTP1 genes polymorphisms with susceptibility to osteosarcoma: a case-control study and meta-analysis. Asian Pacific Journal of Cancer Prevention: APJCP, 20(3), 675.

Li, G., Cai, Y., Wang, C., Huang, M., & Chen, J. (2019). LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cells. Journal of neuro-oncology, 143, 525-536.

Llavanera, M., Delgado-Bermúdez, A., Fernandez-Fuertes, B., Recuero, S., Mateo, Y., Bonet, S., ... & Yeste, M. (2019). GSTM3, but not IZUMO1, is a cryotolerance marker of boar sperm. Journal of animal science and biotechnology, 10(1), 1-11.

Checa-Rojas, A., Delgadillo-Silva, L. F., del Castillo Velasco-Herrera, M., Andrade-Domínguez, A., Gil, J., Santillán, O., ... & Encarnación-Guevara, S. (2018). GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer. Oncotarget, 9(31), 21696.

Wang, Y., Yang, Z. Y., Chen, Y. H., Li, F., Shen, H., Yu, Y., ... & Shen, Z. Y. (2018). A novel functional polymorphism of GSTM 3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR‐556 binding. Journal of Cellular and Molecular Medicine, 22(6), 3005-3015.

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For research use only. Not intended for any clinical use.

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