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Mouse Anti-GSTM1 Recombinant Antibody (CBMAB-BR195LY)


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Summary

Host Animal
Mouse
Specificity
Human
Antibody Isotype
IgG1
Application
FC: 1-3 μg/1x10 cells

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence of human GSTM1 (EEEKIRVDIL ENQTMDNHMQLGMICYNPEFEKLK)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutathione S-transferase mu 1
Introduction
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2944
UniProt ID
P09488
Alternative Names
Glutathione S-transferase Mu 1; GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GSTM1; GST1
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).
Biological Process
Cellular detoxification of nitrogen compound Source: BHF-UCL
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: BHF-UCL
Hepoxilin biosynthetic process Source: UniProtKB
Nitrobenzene metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic catabolic process Source: BHF-UCL
Cellular Location
Cytoplasm
More Infomation

Nakanishi, G., Bertagnolli, L. S., Pita-Oliveira, M., Scudeler, M. M., Torres-Loureiro, S., Almeida-Dantas, T., ... & Rodrigues-Soares, F. (2022). GSTM1 and GSTT1 polymorphisms in healthy volunteers–a worldwide systematic review. Drug Metabolism Reviews, 54(1), 37-45.

Levy, R. V., Reidy, K. J., Le, T. H., David, V., Winkler, C., Xu, Y., ... & Melamed, M. L. (2022). Association of GSTM1 deletion with progression of CKD in children: Findings from the chronic kidney disease in children (CKiD) study. American Journal of Kidney Diseases, 80(1), 79-86.

Abbas, M., Verma, S., Verma, S., Siddiqui, S., Khan, F. H., Raza, S. T., ... & Mahdi, F. (2021). Association of GSTM1 and GSTT1 gene polymorphisms with COVID‐19 susceptibility and its outcome. Journal of medical virology, 93(9), 5446-5451.

Singh, P., Wang, X., Hageman, L., Chen, Y., Magdy, T., Landier, W., ... & Bhatia, S. (2020). Association of GSTM1 null variant with anthracycline‐related cardiomyopathy after childhood cancer—A Children's Oncology Group ALTE03N1 report. Cancer, 126(17), 4051-4058.

Chanhom, N., Udomsinprasert, W., Mahasirimongkol, S., Wattanapokayakit, S., & Jittikoon, J. (2020). GSTM1 and GSTT1 genetic polymorphisms and their association with antituberculosis drug‑induced liver injury. Biomedical Reports, 12(4), 153-162.

Song, L., Yang, C., & He, X. F. (2020). Individual and combined effects of GSTM1 and GSTT1 polymorphisms on colorectal cancer risk: an updated meta-analysis. Bioscience Reports, 40(8).

Li, S., Xue, F., Zheng, Y., Yang, P., Lin, S., Deng, Y., ... & Chen, S. (2019). GSTM1 and GSTT1 null genotype increase the risk of hepatocellular carcinoma: evidence based on 46 studies. Cancer cell international, 19(1), 1-12.

Kalacas, N. A., Garcia, J. A., Ortin, T. S., Valdez Jr, A., Fellizar, A., Ramos, M. C., & Albano, P. M. (2019). GSTM1 and GSTT1 genetic polymorphisms and breast cancer risk in selected Filipino cases. Asian Pacific journal of cancer prevention: APJCP, 20(2), 529.

Grubisa, I., Otasevic, P., Vucinic, N., Milicic, B., Jozic, T., Krstic, S., & Milasin, J. (2018). Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population. Genetics and molecular biology, 41, 35-40.

Klusek, J., Nasierowska-Guttmejer, A., Kowalik, A., Wawrzycka, I., Lewitowicz, P., Chrapek, M., & Głuszek, S. (2018). GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers. Oncotarget, 9(30), 21224.

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For research use only. Not intended for any clinical use.

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