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Mouse Anti-GSN Recombinant Antibody (CBLG1-1922) (CBMAB-G5301-LY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBLG1-1922
Antibody Isotype
IgG2a
Application
IF, IHC-Fr, IHC-P, IP, WB

Basic Information

Specificity
Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Buffer
2 mg BSA
Preservative
0.01 mg sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Gelsolin
Introduction
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
296654
UniProt ID
Q68FP1
Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Biological Process
Actin filament capping Source: UniProtKB
Actin filament depolymerization Source: BHF-UCL
Actin filament polymerization Source: UniProtKB
Actin filament reorganization Source: UniProtKB
Actin filament severing Source: UniProtKB
Actin nucleation Source: InterPro
Actin polymerization or depolymerization Source: GO_Central
Amyloid fibril formation Source: UniProtKB
Barbed-end actin filament capping Source: GO_Central
Cardiac muscle cell contraction Source: BHF-UCL
Cell projection assembly Source: GO_Central
Cellular response to interferon-gamma Source: Ensembl
Central nervous system development Source: GO_Central
Cilium assembly Source: UniProtKB
Hepatocyte apoptotic process Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Phagocytosis, engulfment Source: UniProtKB
Positive regulation of actin nucleation Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of keratinocyte apoptotic process Source: UniProtKB
Positive regulation of protein processing in phagocytic vesicle Source: UniProtKB
Protein destabilization Source: UniProtKB
Regulation of establishment of T cell polarity Source: UniProtKB
Regulation of plasma membrane raft polarization Source: UniProtKB
Regulation of podosome assembly Source: UniProtKB
Regulation of receptor clustering Source: UniProtKB
Relaxation of cardiac muscle Source: BHF-UCL
Renal protein absorption Source: UniProtKB
Response to muscle stretch Source: BHF-UCL
Sequestering of actin monomers Source: UniProtKB
Striated muscle atrophy Source: UniProtKB
Cellular Location
Isoform 2: Cytoskeleton
Isoform 1: Secreted
Involvement in disease
Amyloidosis 5 (AMYL5):
A hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
PTM
Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
More Infomation

Zhang, Q., Tang, S. L., Zhao, Z. W., & Tang, C. K. (2023). Role and therapeutic potential of gelsolin in atherosclerosis. Journal of Molecular and Cellular Cardiology.

Onuma, T., Asare-Werehene, M., Yoshida, Y., & Tsang, B. K. (2022). Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance. Cells, 11(20), 3305.

Wu, Y., Zheng, J., Yan, Y., Liu, J., & Zhou, Y. (2022). Gelsolin can be a prognostic biomarker and correlated with immune infiltrates in gastric cancer. International Journal of General Medicine, 927-936.

Feldt, J., Schicht, M., Welss, J., Gelse, K., Sesselmann, S., Tsokos, M., ... & Paulsen, F. (2022). Production and secretion of gelsolin by both human macrophage-and fibroblast-like synoviocytes and GSN modulation in the synovial fluid of patients with various forms of arthritis. Biomedicines, 10(3), 723.

Potrč, M., Volk, M., de Rosa, M., Pižem, J., Teran, N., Jaklič, H., ... & Fakin, A. (2021). Clinical and histopathological features of gelsolin amyloidosis associated with a novel GSN variant p. Glu580Lys. International journal of molecular sciences, 22(3), 1084.

Jana, S., Aujla, P., Hu, M., Kilic, T., Zhabyeyev, P., McCulloch, C. A., ... & Kassiri, Z. (2021). Gelsolin is an important mediator of Angiotensin II‐induced activation of cardiac fibroblasts and fibrosis. The FASEB Journal, 35(10), e21932.

Zhang, Y., Luo, X., Lin, J., Fu, S., Feng, P., Su, H., ... & Deng, W. (2020). Gelsolin promotes cancer progression by regulating epithelial-mesenchymal transition in hepatocellular carcinoma and correlates with a poor prognosis. Journal of Oncology, 2020.

Chen, Z., Li, K., Yin, X., Li, H., Li, Y., Zhang, Q., ... & Qiu, Y. (2019). Lower expression of gelsolin in colon cancer and its diagnostic value in colon cancer patients. Journal of Cancer, 10(5), 1288.

Wittmann, J., Dieckow, J., Schröder, H., Hampel, U., Garreis, F., Jacobi, C., ... & Schicht, M. (2018). Plasma gelsolin promotes re-epithelialization. Scientific Reports, 8(1), 13140.

Feldt, J., Schicht, M., Garreis, F., Welss, J., Schneider, U. W., & Paulsen, F. (2018). Structure, regulation and related diseases of the actin-binding protein gelsolin. Expert reviews in molecular medicine, 20, e7.

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For research use only. Not intended for any clinical use.

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