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Rabbit Anti-GSDMA Recombinant Antibody (CBLG1-2983) (CBMAB-G5128-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBLG1-2983
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.456 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
gasdermin A
Entrez Gene ID
Human284110
Mouse57911
Rat360619
UniProt ID
HumanQ96QA5
MouseQ9EST1
RatD3ZA32
Function
Gasdermin-A:
This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death.

Gasdermin-A, N-terminal:
Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216).

Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids (PubMed:27281216).

Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216).

Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:27281216).

The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (PubMed:27281216).
Biological Process
Apoptotic process Source: UniProtKB
Defense response to bacterium Source: GO_Central
Pyroptosis Source: GO_Central
Cellular Location
Gasdermin-A: Cytosol; Perinuclear region
Gasdermin-A, N-terminal: Cell membrane
PTM
Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-A, N-terminal) that initiates pyroptosis.
More Infomation

Deng, W., Bai, Y., Deng, F., Pan, Y., Mei, S., Zheng, Z., ... & Liu, X. (2022). Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature, 602(7897), 496-502.

LaRock, D. L., Johnson, A. F., Wilde, S., Sands, J. S., Monteiro, M. P., & LaRock, C. N. (2022). Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes. Nature, 605(7910), 527-531.

Symmank, J., Jacobs, C., & Schulze-Späte, U. (2022). Suicide signaling by GSDMA: a single-molecule mechanism for recognition and defense against SpeB-expressing GAS. Signal Transduction and Targeted Therapy, 7(1), 153.

Deng, W., Bai, Y., Deng, F., Pan, Y., Mei, S., Zheng, Z., ... & Liu, X. (2022). Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature, 608(7923), E28-E28.

Gagnon, M. F., Provost, S., Ayachi, S., Buscarlet, M., Mollica, L., Dubé, M. P., & Busque, L. (2021). Quantitative Trait of Neutrophil Count Is Influenced By Variants in the Region of Gsdma and PSMD3-CSF3, aging, Cardiometabolic Comorbidities but Not By Chip. Blood, 138, 1089.

Gatineau-Sailliant, S., Glisovic, S., Gagne, V., Laverdière, C., Leclerc, J. M., Silverman, L. B., ... & Pastore, Y. (2019). Impact of DARC, GSDMA and CXCL2 polymorphisms on induction toxicity in children with acute lymphoblastic leukemia: A complementary study. Leukemia research, 86, 106228.

Madore, A. M., Pain, L., Boucher-Lafleur, A. M., Meloche, J., Morin, A., Simon, M. M., ... & Laprise, C. (2019). GSDMA drives the most replicated association with asthma in naïve CD4+ T cells. bioRxiv, 774760.

Moreno-Moral, A., Bagnati, M., Koturan, S., Ko, J. H., Fonseca, C., Harmston, N., ... & Petretto, E. (2018). Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk. Annals of the rheumatic diseases, 77(4), 596-601.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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