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Mouse Anti-GPX3 Recombinant Antibody (CBLG1-1676) (CBMAB-G4742-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1676
Antibody Isotype
IgG2b, κ
Application
ELISA, IP

Basic Information

Immunogen
Recombinant human GPX3 purified from E. coli
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GLUTATHIONE PEROXIDASE 3
Introduction
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Entrez Gene ID
2878
UniProt ID
P22352
Alternative Names
Glutathione Peroxidase 3; Extracellular Glutathione Peroxidase; Glutathione Peroxidase 3 (Plasma); Plasma Glutathione Peroxidase; EC 1.11.1.9; GSHPx-3;
Function
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Biological Process
Hydrogen peroxide catabolic process Source: GO_Central
Response to lipid hydroperoxide Source: UniProtKB
Cellular Location
Secreted
PTM
The N-terminus is blocked.
More Infomation

Demircan, K., Bengtsson, Y., Sun, Q., Brange, A., Vallon-Christersson, J., Rijntjes, E., ... & Schomburg, L. (2021). Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study. Redox Biology, 47, 102145.

Chang, C., Worley, B. L., Phaëton, R., & Hempel, N. (2020). Extracellular glutathione peroxidase GPx3 and its role in cancer. Cancers, 12(8), 2197.

Ling, P., Shan, W., Zhai, G., Qiu, C., Liu, Y., Xu, Y., & Yang, X. (2020). Association between glutathione peroxidase‐3 activity and carotid atherosclerosis in patients with type 2 diabetes mellitus. Brain and behavior, 10(10), e01773.

Yi, Z., Jiang, L., Zhao, L., Zhou, M., Ni, Y., Yang, Y., ... & Zhu, Y. (2019). Glutathione peroxidase 3 (GPX3) suppresses the growth of melanoma cells through reactive oxygen species (ROS)‐dependent stabilization of hypoxia‐inducible factor 1‐α and 2‐α. Journal of cellular biochemistry, 120(11), 19124-19136.

Tu, Y., Li, L., Qin, B., Wu, J., Cheng, T., Kang, L., & Guan, H. (2019). Long noncoding RNA glutathione peroxidase 3–antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract. Molecular Vision, 25, 734.

Lee, W. J., Chen, Y. L., Chu, Y. W., & Chien, D. S. (2019). Comparison of glutathione peroxidase-3 protein expression and enzyme bioactivity in normal subjects and patients with sepsis. Clinica Chimica Acta, 489, 177-182.

Zhao, L., Zong, W., Zhang, H., & Liu, R. (2019). Kidney toxicity and response of selenium containing protein-glutathione peroxidase (Gpx3) to CdTe QDs on different levels. Toxicological Sciences, 168(1), 201-208.

Langhardt, J., Flehmig, G., Klöting, N., Lehmann, S., Ebert, T., Kern, M., ... & Blüher, M. (2018). Effects of weight loss on glutathione peroxidase 3 serum concentrations and adipose tissue expression in human obesity. Obesity facts, 11(6), 475-490.

Qi, X., Ng, K. T. P., Lian, Q., Li, C. X., Geng, W., Ling, C. C., ... & Man, K. (2018). Glutathione peroxidase 3 delivered by hiPSC-MSCs ameliorated hepatic IR injury via inhibition of hepatic senescence. Theranostics, 8(1), 212.

Pang, P., Abbott, M., Abdi, M., Fucci, Q. A., Chauhan, N., Mistri, M., ... & Siedlecki, A. M. (2018). Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrology Dialysis Transplantation, 33(6), 923-934.

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For research use only. Not intended for any clinical use.

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