Mouse Anti-GPT Recombinant Antibody (M1) (CBMAB-G4711-LY)

Name: Mouse Anti-GPT Recombinant Antibody (M1)
SKU: CBMAB-G4711-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Cat

Clone

Antibody Isotype

IgG1

Application

ELISA

Basic Information

Immunogen

GPT (AAH18207, 1 a.a. ~ 497 a.a) full length recombinant protein

Specificity

Human, Cat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Glutamic--Pyruvic Transaminase

Introduction

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

Entrez Gene ID

Human	2875
Cat	101097207

UniProt ID

Human	P24298
Cat	A0A380W7L2

Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).

Biological Process

Biosynthetic process Source: InterPro
Cellular response to insulin stimulus Source: Ensembl
L-alanine catabolic process Source: UniProtKB-UniPathway
Positive regulation of gluconeogenesis Source: Ensembl
Response to starvation Source: Ensembl

Cellular Location

Cytoplasm

More Infomation

References

Guo, W., Tan, H. Y., Li, S., Wang, N., & Feng, Y. (2020). Glutamic-pyruvic transaminase 1 facilitates alternative fuels for hepatocellular carcinoma growth—a small molecule inhibitor, berberine. Cancers, 12(7), 1854.

Guardiola-Arévalo, A., Rodríguez, R. G., Gutiérrez, M. R., Moreno, A. Z. G., Vela, A. G., Simón, R. S., ... & Esteban, E. M. A. (2018). Hepatitis B virus e antigen-negative chronic infection. Treatment based on glutamic pyruvic transaminase and hepatitis B virus deoxyribonucleic acid cut-off values. Gastroenterología y Hepatología (English Edition), 41(3), 153-162.

Shih, Y. L., Hsueh, S. C., Chen, Y. L., Chou, J. S., Chung, H. Y., Liu, K. L., ... & Chung, J. G. (2018). Laminarin promotes immune responses and reduces lactate dehydrogenase but increases glutamic pyruvic transaminase in normal mice in vivo. in vivo, 32(3), 523-529.

Shang, H. S., Shih, Y. L., Chen, C. P., Lee, M. H., Lu, H. F., Chou, P. Y., ... & Chung, J. G. (2018). Laminarin promotes immune responses and normalizes glutamic oxaloacetic transaminase and glutamic pyruvic transaminase levels in leukemic mice in vivo. in vivo, 32(4), 783-790.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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