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Mouse Anti-GORASP1 Recombinant Antibody (CBFYH-0424) (CBMAB-H1295-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0424
Antibody Isotype
IgG2b
Application
IF, WB

Basic Information

Immunogen
Full length recombinant protein of human GORASP1 produced in HEK293T cells
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
golgi reassembly stacking protein 1
Introduction
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene.
Entrez Gene ID
64689
UniProt ID
Q9BQQ3
Alternative Names
Golgi Reassembly Stacking Protein 1; Golgi Phosphoprotein 5; Golgi Reassembly-Stacking Protein Of 65 KDa; Golgi Reassembly Stacking Protein 1, 65kDa; Golgi Peripheral Membrane Protein P65; GRASP65
Function
Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069).

Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity).

Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).

Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936).
Biological Process
Establishment of protein localization to plasma membrane Source: UniProtKB
Golgi organization Source: UniProtKB
Negative regulation of dendrite morphogenesis Source: UniProtKB
Protein N-linked glycosylation Source: Ensembl
Protein transport Source: UniProtKB-KW
Cellular Location
Cis-Golgi network membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane
PTM
Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking.By similarity
Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis.By similarity
Myristoylated.By similarity
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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