Human Anti-GOLGB1 Recombinant Antibody (CBFYH-3461) (CBMAB-H4009-FY)

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Datasheet

Summary

Host Animal

Human

Specificity

Human

Clone

CBFYH-3461

Antibody Isotype

IgG2, λ

Application

ICC

Basic Information

Immunogen

Human recombinant giantin

Specificity

Human

Antibody Isotype

IgG2, λ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95% by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

golgin B1, golgi integral membrane protein

Introduction

The Golgb1 gene encodes the COPI vesicle tethering factor, giantin.

Entrez Gene ID

2804

UniProt ID

Q14789

Alternative Names

GCP; GCP372; GOLIM10

Function

May participate in forming intercisternal cross-bridges of the Golgi complex.

Biological Process

Chondrocyte proliferation Source: Ensembl
Golgi organization Source: ProtInc
Protein localization to pericentriolar material Source: GO_Central
Regulation of transcription, DNA-templated Source: InterPro

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-3235
Helical: 3236-3256
Lumenal: 3257-3259

More Infomation

References

Liu, F. R., Zhou, Y., Wang, Y., Huang, L. L., Zhang, X., Luo, H., ... & Zhang, Y. W. (2022). Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder. Translational Psychiatry, 12(1), 390.

Bubola, J., Antonescu, C. R., Weinreb, I., Swanson, D., De Almeida, J. R., MacMillan, C. M., & Dickson, B. C. (2021). A novel low‐grade nasopharyngeal adenocarcinoma characterized by a GOLGB1‐BRAF fusion gene. Genes, Chromosomes and Cancer, 60(1), 49-53.

Fu, R., Ren, T., Li, W., Liang, J., Mo, G., Luo, W., ... & Zhang, X. (2020). A novel 65-bp Indel in the GOLGB1 gene is associated with chicken growth and carcass traits. Animals, 10(3), 475.

Kotu, V., Dubrelle, J., Baker, J., Jenson, K., & Flanagan, J. M. (2018). A Genetic Variant in GOLGB1 Affects Golgi Function and Stroke Risk in Patients with Sickle Cell Disease. Blood, 132, 3649.

Machado, R. A., Martelli‐Júnior, H., de Almeida Reis, S. R., Persuhn, D. C., & Coletta, R. D. (2018). Association between GOLGB1 tag‐polymorphisms and nonsyndromic cleft palate only in the Brazilian population. Annals of Human Genetics, 82(4), 227-231.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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