Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-GJB6 Monoclonal Antibody (16H9L8) (CBMAB-1332-YC)


See all GJB6 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
16H9L8
Antibody Isotype
IgG
Application
ICC, IF, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide corresponding to Mouse GJB6 (aa 241-261)
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Gap Junction Protein Beta 6
Introduction
Connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. GJB6 is one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
Entrez Gene ID
14623
UniProt ID
P70689
Alternative Names
Cx30; AA958971; D14Bwg0506e
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Biological Process
Aging Source: Ensembl
Apoptotic process Source: Ensembl
Cell-cell signaling Source: GO_Central
Cellular response to glucose stimulus Source: Ensembl
Ear morphogenesis Source: Ensembl
Gap junction assembly Source: ARUK-UCL
Gap junction-mediated intercellular transport Source: ARUK-UCL
Inner ear development Source: Ensembl
Maintenance of blood-brain barrier Source: ARUK-UCL
Negative regulation of cell population proliferation Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of sound Source: ProtInc
Sinoatrial node development Source: BHF-UCL
Transmembrane transport Source: ARUK-UCL
Cellular Location
Cell membrane; Gap junction
Involvement in disease
Ectodermal dysplasia 2, Clouston type (ECTD2):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD2 is an autosomal dominant condition characterized by atrichosis, nail hypoplasia and deformities, hyperpigmentation of the skin, normal teeth, normal sweat and sebaceous gland function. Palmoplantar hyperkeratosis is a frequent feature. Hearing impairment has been detected in few cases.
Deafness, autosomal recessive, 1B (DFNB1B):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Deafness, autosomal dominant, 3B (DFNA3B):
A form of non-syndromic sensorineural hearing loss characterized by a variable phenotype, ranging from bilateral middle to high frequency hearing loss to profound sensorineural deafness. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Cytoplasmic: 1-22
Helical: 23-45
Extracellular: 46-75
Helical: 76-98
Cytoplasmic: 99-131
Helical: 132-154
Extracellular: 155-192
Helical: 193-215
Cytoplasmic: 216-261
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-GJB6 Monoclonal Antibody (16H9L8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry