Recombinant Mouse Anti-GHRL Antibody (CB2178) (CBMAB-MD1140-LY)

Mouse

Human

CB2178

IgG3

ELISA

Des-acyl ghrelin (synthetic)

Human

IgG3

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

PBS, pH 7.4

0.09 % Sodium Azide

> 95% Purity determined by SDS-PAGE

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Ghrelin And Obestatin Prepropeptide

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.

Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).

Actin polymerization or depolymerization Source: UniProtKB
Activation of MAPK activity Source: UniProtKB
Adult feeding behavior Source: HGNC-UCL
Cartilage development Source: UniProtKB
Cortisol secretion Source: UniProtKB
Decidualization Source: UniProtKB
Dendrite development Source: MGI
Excitatory postsynaptic potential Source: Ensembl
Gastric acid secretion Source: GO_Central
Gastric emptying Source: Ensembl
Glucose metabolic process Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
Growth hormone secretion Source: HGNC-UCL
Hormone-mediated signaling pathway Source: HGNC-UCL
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of circadian sleep/wake cycle, REM sleep Source: BHF-UCL
Negative regulation of endothelial cell proliferation Source: UniProtKB
Negative regulation of inflammatory response Source: UniProtKB
Negative regulation of insulin secretion Source: Ensembl
Negative regulation of interleukin-1 beta production Source: UniProtKB
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of locomotion Source: Ensembl
Negative regulation of tumor necrosis factor production Source: UniProtKB
Positive regulation of adipose tissue development Source: Ensembl
Positive regulation of appetite Source: HGNC-UCL
Positive regulation of bone development Source: Ensembl
Positive regulation of circadian sleep/wake cycle, non-REM sleep Source: BHF-UCL
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of corticotropin secretion Source: BHF-UCL
Positive regulation of cortisol secretion Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of eating behavior Source: Ensembl
Positive regulation of gastric mucosal blood circulation Source: Ensembl
Positive regulation of growth hormone receptor signaling pathway Source: BHF-UCL
Positive regulation of growth hormone secretion Source: BHF-UCL
Positive regulation of growth rate Source: Ensembl
Positive regulation of insulin secretion Source: UniProtKB
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Positive regulation of multicellular organism growth Source: HGNC-UCL
Positive regulation of small intestinal transit Source: Ensembl
Positive regulation of small intestine smooth muscle contraction Source: Ensembl
Positive regulation of sprouting angiogenesis Source: Ensembl
Positive regulation of synapse assembly Source: MGI
Positive regulation of vascular endothelial cell proliferation Source: Ensembl
Postsynaptic modulation of chemical synaptic transmission Source: Ensembl
Regulation of cell population proliferation Source: UniProtKB
Regulation of gastric motility Source: Ensembl
Regulation of postsynapse organization Source: Ensembl
Regulation of response to food Source: GO_Central
Regulation of transmission of nerve impulse Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to estrogen Source: UniProtKB
Response to hormone Source: UniProtKB

Secreted

O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid (PubMed:10604470).
Amidation of Leu-98 is essential for obestatin activity.