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Mouse Anti-GDF7 (AA 204-301) Recombinant Antibody (CBFYH-0309) (CBMAB-H1180-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0309
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: VGQRWEAFDV ADAMRRHRRE PRPPRAFCLL LRAVAGPVPS PLALRRLGFG WPGGGGSAAE ERAVLVVSSR TQRKESLFRE IRAQARALGA ALASEPLP
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 204-301

Target

Full Name
Growth Differentiation Factor 7
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.
Entrez Gene ID
151449
UniProt ID
Q7Z4P5
Alternative Names
Growth Differentiation Factor 7; GDF-7; Growth/Differentiation Factor 7; BMP12
Function
May play an active role in the motor area of the primate neocortex.
Biological Process
Activin receptor signaling pathway Source: BHF-UCL
Axon guidance Source: Ensembl
BMP signaling pathway Source: BHF-UCL
Branching morphogenesis of an epithelial tube Source: Ensembl
Cell fate commitment Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Forebrain morphogenesis Source: Ensembl
Gland morphogenesis Source: Ensembl
Midbrain development Source: Ensembl
Morphogenesis of an epithelial fold Source: Ensembl
Pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of tendon cell differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Reproductive structure development Source: Ensembl
Roof plate formation Source: Ensembl
SMAD protein signal transduction Source: GO_Central
Spinal cord association neuron differentiation Source: Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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