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Mouse Anti-GCLM Antibody (6BA14) (CBMAB-1257CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6BA14
Antibody Isotype
IgG2a
Application
ELISA

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutamate-Cysteine Ligase Modifier Subunit
Introduction
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Diseases associated with GCLM include Myocardial Infarction and Ancylostomiasis. Among its related pathways are Glutathione metabolism and Metabolism.
Entrez Gene ID
2730
UniProt ID
P48507
Alternative Names
Glutamate-Cysteine Ligase Modifier Subunit; Glutamate-Cysteine Ligase; Modifier Subunit; Gamma-Glutamylcysteine Synthetase Regulatory Subunit; Gamma-ECS Regulatory Subunit; GCS Light Chain; GLCLR; Glutamate-Cysteine Ligase (Gamma-Glutamylcysteine Synthetase); Regulatory (30.8kD); Glutamate-Cysteine Ligase Modifier Subunit Delta2 Alternative Splicing; Glutamate-Cysteine Ligase Regulatory Protein; Glutamate--Cysteine Ligase Modifier Subunit; Gamma-Glutamylcysteine Synthetase; GSC Light Chain
Function
Aging Source: Ensembl
Apoptotic mitochondrial changes Source: Ensembl
Blood vessel diameter maintenance Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: Ensembl
Cellular response to follicle-stimulating hormone stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Cellular response to thyroxine stimulus Source: Ensembl
Cysteine metabolic process Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glutathione biosynthetic process Source: UniProtKB
Hepatic stellate cell activation Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Positive regulation of glutamate-cysteine ligase activity Source: GO_Central
Regulation of mitochondrial depolarization Source: Ensembl
Response to activity Source: Ensembl
Response to drug Source: UniProtKB
Response to human chorionic gonadotropin Source: Ensembl
Response to nitrosative stress Source: Ensembl
Response to nutrient Source: Ensembl
Response to oxidative stress Source: UniProtKB
Biological Process
Cytosol; Glutamate-cysteine ligase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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