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Mouse Anti-GALT Monoclonal Antibody (4C11) (CBMAB-1319-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
4C11
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
The full-length recombinant protein GALT (AAH15045, aa 1-379) with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Galactose-1-Phosphate Uridylyltransferase
Introduction
GALT catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of GALT results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet.
Entrez Gene ID
Human2592
Rat298003
UniProt ID
HumanP07902
RatP43424
Alternative Names
UDP-glucose--hexose-1-phosphate uridylyltransferase; EC 2.7.7.12; gal-1-P uridylyltransferase; galactose-1-phosphate uridyl transferase
Function
Plays an important role in galactose metabolism.
Biological Process
Galactose catabolic process Source: Reactome
Galactose catabolic process via UDP-galactose Source: GO_Central
Galactose metabolic process Source: UniProtKB
UDP-glucose catabolic process Source: Ensembl
UDP-glucose metabolic process Source: UniProtKB
Cellular Location
Cytosol; Golgi apparatus; Cytoplasm
Involvement in disease
Galactosemia 1 (GALAC1):
A form of galactosemia, an inborn error of galactose metabolism typically manifesting in the neonatal period, after ingestion of galactose, with jaundice, hepatosplenomegaly, hepatocellular insufficiency, food intolerance, hypoglycemia, renal tubular dysfunction, muscle hypotonia, sepsis and cataract. GALAC1 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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