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Mouse Anti-GAD2 Recombinant Antibody (CBLG1-483) (CBMAB-G1756-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Monkey, Rat
Clone
CBLG1-483
Antibody Isotype
IgG1
Application
IHC-P, IP, RIA, WB

Basic Information

Immunogen
Keyhole Limpet Haemocyanin (KLH) conjugated synthetic peptide sequence PGSGFWSFGSEDGSGDSEN corresponding to amino acids 4-22 within the N-terminal region of human GAD65
Specificity
Human, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutamate Decarboxylase 2
Introduction
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Entrez Gene ID
Human2572
Monkey613029
Rat24380
UniProt ID
HumanQ05329
MonkeyA0A2K5W1T4
RatQ05683
Alternative Names
Glutamate Decarboxylase 2; Glutamate Decarboxylase 2 (Pancreatic Islets And Brain; 65kDa); Glutamate Decarboxylase 65 KDa Isoform; 5 KDa Glutamic Acid Decarboxylase; EC 4.1.1.15; GAD-65;
Function
Catalyzes the production of GABA.
Biological Process
Chemical synaptic transmission Source: ProtInc
Glutamate decarboxylation to succinate Source: ProtInc
Neurotransmitter biosynthetic process Source: UniProtKB-KW
Response to drug Source: Ensembl
Cellular Location
Cytosol; Presynaptic cell membrane; Golgi apparatus membrane; Cytoplasmic vesicle. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
PTM
Phosphorylated; which does not affect kinetic parameters or subcellular location.
Palmitoylated; which is required for presynaptic clustering.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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