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Mouse Anti-GAD1 Recombinant Antibody (CBLG1-472) (CBMAB-G1728-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
CBLG1-472
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Streptozotocin
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutamate Decarboxylase 1
Introduction
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human2571
Mouse14415
Rat24379
Monkey613030
UniProt ID
HumanQ99259
MouseP48318
RatP18088
MonkeyG7N8A4
Function
Catalyzes the production of GABA.
Biological Process
Chemical synaptic transmission Source: ProtInc
Gamma-aminobutyric acid biosynthetic process Source: Ensembl
Glutamate catabolic process Source: UniProtKB
Glutamate decarboxylation to succinate Source: ProtInc
Locomotory exploration behavior Source: Ensembl
Neurotransmitter biosynthetic process Source: UniProtKB-KW
Protein-pyridoxal-5-phosphate linkage Source: UniProtKB
Response to drug Source: Ensembl
Social behavior Source: Ensembl
Cellular Location
Plasma membrane; Axon terminus; Cell cortex; Clathrin-sculpted gamma-aminobutyric acid transport vesicle; Inhibitory synapse; Presynaptic active zone; Vesicle membrane
Involvement in disease
Cerebral palsy, spastic quadriplegic 1 (CPSQ1):
A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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