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Rabbit Anti-GABRE Recombinant Antibody (S413-67) (CBMAB-1550-CN)


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Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
S413-67
Antibody Isotype
IgG2a
Application
WB, ICC, IF, IHC

Basic Information

Immunogen
Fusion protein aa. 27-253 (Extracellular N-terminus) of human GABA A Receptor Epsilon
Specificity
Human, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.1% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in aa. 27-253

Target

Full Name
Gamma-Aminobutyric Acid Type A Receptor Epsilon Subunit
Introduction
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Entrez Gene ID
Human2564
Rat65191
UniProt ID
HumanP78334
RatQ9ES14
Alternative Names
gamma-aminobutyric acid receptor subunit epsilon; GABA(A) receptor subunit epsilon; GABA(A) receptor, epsilon; gamma-aminobutyric acid (GABA) A receptor, epsilon
Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Biological Process
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: GO_Central
Gamma-aminobutyric acid signaling pathway Source: GO_Central
Ion transmembrane transport Source: GO_Central
Negative regulation of chloride transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Regulation of postsynaptic membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, GABAergic Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane
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For research use only. Not intended for any clinical use.

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