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Rabbit Anti-GABARAPL1 Recombinant Antibody (D5R9Y) (CBMAB-G0114-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D5R9Y
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Synthetic peptide corresponding to human GABARAPL1 at N-terminal
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 100 ug/ml BSA
Preservative
0.02% sodium azide, 150mM sodium chloride
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GABA Type A Receptor Associated Protein Like 1
Entrez Gene ID
Human23710
Mouse57436
Rat689161
UniProt ID
HumanQ9H0R8
MouseQ8R3R8
RatQ0VGK0
Alternative Names
APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1
Function
Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922).

Involved in formation of autophagosomal vacuoles (PubMed:20404487).

While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487).

Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).
Biological Process
Autophagosome assembly Source: GO_Central
Autophagy of mitochondrion Source: GO_Central
Cellular response to nitrogen starvation Source: GO_Central
Macroautophagy Source: GO_Central
Cellular Location
Cytoskeleton; Golgi apparatus; Endoplasmic reticulum; Autophagosome; Cytoplasmic vesicle membrane
PTM
The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I (PubMed:20404487). This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (PubMed:20404487). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (PubMed:20404487).
(Microbial infection) The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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