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Mouse Anti-FTL Recombinant Antibody (FTL/1388) (CBMAB-0313CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
FTL/1388
Antibody Isotype
IgG2a
Application
IHC-P

Basic Information

Immunogen
Human Ferritin Light Chain aa 38-165
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ferritin Light Chain
Introduction
This gene encodes the light subunit of the ferritin protein. FTH subunits exhibit ferroxidase activity, converting Fe(2+) to Fe(3+), so that iron may be stored in the ferritin mineral core, which prevents undesirable reactions of Fe(2+) with oxygen. FTL subunits are devoid of catalytic activity but are thought to facilitate nucleation and mineralization of the iron center. Brown et al. (1983) noted that mammalian liver and spleen ferritin (relative mass about 450 kD) consists of 24 subunits of 2 species, the heavy subunit (relative mass, 21 kD) and the light subunit (relative mass, 19 kD). They presented evidence that, in rat, the 2 subunits are coded by separate mRNAs and that a family of genes encodes the light subunit. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
Entrez Gene ID
2512
UniProt ID
P02792
Alternative Names
Ferritin, Light Polypeptide; Ferritin L Subunit; Ferritin Light Polypeptide-Like 3; Ferritin L-Chain; Neurodegeneration With Brain Iron Accumulation; Ferritin Light Chain; L Apoferritin; NBIA3; LFTD
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Biological Process
Cellular iron ion homeostasis Source: ProtInc
Intracellular sequestering of iron ion Source: GO_Central
Iron ion homeostasis Source: UniProtKB
Iron ion transport Source: InterPro
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Autolysosome; Azurophil granule lumen; Cytoplasm; Intracellular ferritin complex; Membrane
Involvement in disease
Hyperferritinemia with or without cataract (HRFTC):
An autosomal dominant disease characterized by elevated level of ferritin in serum and tissues, and early-onset bilateral cataract. Cataracts may be subclinical in some patients.
Neurodegeneration with brain iron accumulation 3 (NBIA3):
A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild non-progressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
L-ferritin deficiency (LFTD):
A condition characterized by low levels of ferritin in serum and tissues in the absence of other hematological symptoms. Seizures and mild neuropsychologic impairment may manifest in individuals with complete ferritin deficiency.
More Infomation

Yang, X., Ding, Y., Sun, L., Shi, M., Zhang, P., Huang, Z., ... & Li, R. (2022). Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling. Redox Biology, 58, 102555.

Kurzawa‐Akanbi, M., Keogh, M., Tsefou, E., Ramsay, L., Johnson, M., Keers, S., ... & Morris, C. M. (2021). Neuropathological and biochemical investigation of Hereditary Ferritinopathy cases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress. Neuropathology and Applied Neurobiology, 47(1), 26-42.

Wang, Y., Qiu, S., Wang, H., Cui, J., Tian, X., Miao, Y., ... & Zhang, X. (2021). Transcriptional repression of ferritin light chain increases ferroptosis sensitivity in lung adenocarcinoma. Frontiers in Cell and Developmental Biology, 9, 719187.

Hao, S., Zhang, Y., Hua, L., Xie, N., Xiao, N., Wang, H., ... & Shao, Z. (2020). Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immune‑related pancytopenia. Molecular Medicine Reports, 22(3), 2012-2020.

Liu, J., Gao, L., Zhan, N., Xu, P., Yang, J. A., Yuan, F. E., ... & Chen, Q. (2020). Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. Journal of Experimental & Clinical Cancer Research, 39, 1-17.

Li, Z., Liu, J., Chen, H., Zhang, Y., Shi, H., Huang, L., ... & Wang, T. (2020). Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer. Carcinogenesis, 41(4), 467-477.

Pulos-Holmes, M. C., Srole, D. N., Juarez, M. G., Lee, A. S., McSwiggen, D. T., Ingolia, N. T., & Cate, J. H. (2019). Repression of ferritin light chain translation by human eIF3. Elife, 8, e48193.

Bertoli, S., Paubelle, E., Bérard, E., Saland, E., Thomas, X., Tavitian, S., ... & Récher, C. (2019). Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia. European journal of haematology, 102(2), 131-142.

Zarjou, A., Black, L. M., McCullough, K. R., Hull, T. D., Esman, S. K., Boddu, R., ... & Bolisetty, S. (2019). Ferritin light chain confers protection against sepsis-induced inflammation and organ injury. Frontiers in immunology, 10, 131.

Yu, G. H., Fu, L., Chen, J., Wei, F., & Shi, W. X. (2018). Decreased expression of ferritin light chain in osteosarcoma and its correlation with epithelial-mesenchymal transition. Eur Rev Med Pharmacol Sci, 22(9), 2580-2587.

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For research use only. Not intended for any clinical use.

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