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FTL Matched Antibody Pair (453) (APMAB-453LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-FTL monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-FTL Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Alternative Names
Ferritin Light Chain; Ferritin L Subunit; Ferritin Light Polypeptide-Like 3; Ferritin, Light Polypeptide; Ferritin L-Chain; Neurodegeneration With Brain Iron Accumulation 3; L Apoferritin; NBIA3; LFTD;
Entrez Gene ID
2512
UniProt ID
P02792
More Infomation

Yang, X., Ding, Y., Sun, L., Shi, M., Zhang, P., Huang, Z., ... & Li, R. (2022). Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling. Redox Biology, 58, 102555.

Kurzawa‐Akanbi, M., Keogh, M., Tsefou, E., Ramsay, L., Johnson, M., Keers, S., ... & Morris, C. M. (2021). Neuropathological and biochemical investigation of Hereditary Ferritinopathy cases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress. Neuropathology and Applied Neurobiology, 47(1), 26-42.

Wang, Y., Qiu, S., Wang, H., Cui, J., Tian, X., Miao, Y., ... & Zhang, X. (2021). Transcriptional repression of ferritin light chain increases ferroptosis sensitivity in lung adenocarcinoma. Frontiers in Cell and Developmental Biology, 9, 719187.

Hao, S., Zhang, Y., Hua, L., Xie, N., Xiao, N., Wang, H., ... & Shao, Z. (2020). Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immune‑related pancytopenia. Molecular Medicine Reports, 22(3), 2012-2020.

Liu, J., Gao, L., Zhan, N., Xu, P., Yang, J. A., Yuan, F. E., ... & Chen, Q. (2020). Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. Journal of Experimental & Clinical Cancer Research, 39, 1-17.

Li, Z., Liu, J., Chen, H., Zhang, Y., Shi, H., Huang, L., ... & Wang, T. (2020). Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer. Carcinogenesis, 41(4), 467-477.

Pulos-Holmes, M. C., Srole, D. N., Juarez, M. G., Lee, A. S., McSwiggen, D. T., Ingolia, N. T., & Cate, J. H. (2019). Repression of ferritin light chain translation by human eIF3. Elife, 8, e48193.

Bertoli, S., Paubelle, E., Bérard, E., Saland, E., Thomas, X., Tavitian, S., ... & Récher, C. (2019). Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia. European journal of haematology, 102(2), 131-142.

Zarjou, A., Black, L. M., McCullough, K. R., Hull, T. D., Esman, S. K., Boddu, R., ... & Bolisetty, S. (2019). Ferritin light chain confers protection against sepsis-induced inflammation and organ injury. Frontiers in immunology, 10, 131.

Yu, G. H., Fu, L., Chen, J., Wei, F., & Shi, W. X. (2018). Decreased expression of ferritin light chain in osteosarcoma and its correlation with epithelial-mesenchymal transition. Eur Rev Med Pharmacol Sci, 22(9), 2580-2587.

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For research use only. Not intended for any clinical use.

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