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Rabbit Anti-FTH1 Recombinant Antibody (CBXF-2262) (CBMAB-F1898-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-2262
Antibody Isotype
IgG
Application
IF, WB

Basic Information

Immunogen
Peptides corresponding to Human FTH1 (aa 41-54, 77-95)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ferritin Heavy Chain 1
Introduction
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Entrez Gene ID
Human2495
Mouse14319
Rat25319
UniProt ID
HumanP02794
MouseP09528
RatP19132
Alternative Names
Ferritin Heavy Chain 1; Cell Proliferation-Inducing Gene 15 Protein; Proliferation-Inducing Protein 15; Placenta Immunoregulatory Factor; Ferritin, Heavy Polypeptide 1; Ferritin H Subunit; Apoferritin; EC 1.16.3.1;
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Biological Process
Cellular iron ion homeostasis Source: ProtInc
Immune response Source: UniProtKB
Intracellular sequestering of iron ion Source: UniProtKB
Iron ion transport Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of fibroblast proliferation Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Autolysosome; Nucleus; Cytoplasm; Ficolin-1-rich granule lumen; Intracellular ferritin complex; Tertiary granule lumen
Involvement in disease
The disease is caused by variants affecting the gene represented in this entry. In a Japanese family affected by HFE5, a single point mutation has been detected in the iron-responsive element (IRE) in the 5'-UTR of FTH1 mRNA. This mutation leads to an increased binding affinity for iron regulatory protein and thereby to the efficient suppression of mRNA translation. A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
More Infomation

Yang, G., Pan, Q., Lu, Y., Zhu, J., & Gou, X. (2023). miR-29a-5p modulates ferroptosis by targeting ferritin heavy chain FTH1 in prostate cancer. Biochemical and Biophysical Research Communications.

Muhammad, J. S., ElGhazali, G., Shafarin, J., Mohammad, M. G., Abu-Qiyas, A., & Hamad, M. (2022). SARS-CoV-2-induced hypomethylation of the ferritin heavy chain (FTH1) gene underlies serum hyperferritinemia in severe COVID-19 patients. Biochemical and Biophysical Research Communications, 631, 138-145.

Ali, A., Shafarin, J., Abu Jabal, R., Aljabi, N., Hamad, M., Sualeh Muhammad, J., ... & Hamad, M. (2021). Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC. FEBS Open bio, 11(11), 3101-3114.

Li, X., Si, W., Li, Z., Tian, Y., Liu, X., Ye, S., ... & Zhu, M. (2021). miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease. International Journal of Molecular Medicine, 47(4), 1-12.

Bertoli, S., Paubelle, E., Bérard, E., Saland, E., Thomas, X., Tavitian, S., ... & Récher, C. (2019). Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia. European journal of haematology, 102(2), 131-142.

Ravi, V., Madhankumar, A. B., Abraham, T., Slagle-Webb, B., & Connor, J. R. (2019). Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One, 14(9), e0221952.

Huang, H., Qiu, Y., Huang, G., Zhou, X., Zhou, X., & Luo, W. (2019). Value of ferritin heavy chain (FTH1) expression in diagnosis and prognosis of renal cell carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 25, 3700.

Balaratnam, S., West, N., & Basu, S. (2018). A piRNA utilizes HILI and HIWI2 mediated pathway to down-regulate ferritin heavy chain 1 mRNA in human somatic cells. Nucleic Acids Research, 46(20), 10635-10648.

Jin, P., Kang, J., Lee, M. K., & Park, J. W. (2018). Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH. Biochemical and biophysical research communications, 499(3), 475-481.

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For research use only. Not intended for any clinical use.

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