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Mouse Anti-FOXQ1 Recombinant Antibody (4E6) (CBMAB-A3158-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E6
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
FOXQ1 (NP_150285, 110 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FOXQ1
Introduction
FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[supplied by OMIM
Entrez Gene ID
94234
UniProt ID
Q9C009
Alternative Names
HFH1
Function
Plays a role in hair follicle differentiation.
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Hair follicle morphogenesis Source: Ensembl
Negative regulation of neuron apoptotic process Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
More Infomation

Yang, M., Liu, Q., Dai, M., Peng, R., Li, X., Zuo, W., ... & Huang, M. (2022). FOXQ1-mediated SIRT1 upregulation enhances stemness and radio-resistance of colorectal cancer cells and restores intestinal microbiota function by promoting β-catenin nuclear translocation. Journal of Experimental & Clinical Cancer Research, 41(1), 1-20.

Pizzolato, G., Moparthi, L., Söderholm, S., Cantù, C., & Koch, S. (2022). The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes. Journal of Cell Science, 135(19), jcs260082.

Mitchell, A. V., Wu, L., James Block, C., Zhang, M., Hackett, J., Craig, D. B., ... & Wu, G. (2022). FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis. Nature Communications, 13(1), 6548.

Luo, Y., Wang, J., Wang, F., Liu, X., Lu, J., Yu, X., ... & Li, X. (2021). Foxq1 promotes metastasis of nasopharyngeal carcinoma by inducing vasculogenic mimicry via the EGFR signaling pathway. Cell death & disease, 12(5), 411.

Wu, X., Gardashova, G., Lan, L., Han, S., Zhong, C., Marquez, R. T., ... & Xu, L. (2020). Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis. Communications biology, 3(1), 193.

Hong, X., Liu, N., Liang, Y., He, Q., Yang, X., Lei, Y., ... & Li, Y. (2020). Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1. Molecular cancer, 19, 1-16.

Xiang, L., Zheng, J., Zhang, M., Ai, T., & Cai, B. (2020). FOXQ1 promotes the osteogenic differentiation of bone mesenchymal stem cells via Wnt/β-catenin signaling by binding with ANXA2. Stem Cell Research & Therapy, 11(1), 1-10.

Kang, L. J., Yu, Z. H., Cai, J., He, R., Lu, J. T., Hou, C., ... & Feng, Y. M. (2019). Reciprocal transrepression between FOXF2 and FOXQ1 controls basal‐like breast cancer aggressiveness. The FASEB Journal, 33(5), 6564-6573.

Luo, Q., Wang, C. Q., Yang, L. Y., Gao, X. M., Sun, H. T., Zhang, Y., ... & Qin, L. X. (2018). FOXQ1/NDRG1 axis exacerbates hepatocellular carcinoma initiation via enhancing crosstalk between fibroblasts and tumor cells. Cancer letters, 417, 21-34.

Bagati, A., Bianchi-Smiraglia, A., Moparthy, S., Kolesnikova, K., Fink, E. E., Kolesnikova, M., ... & Nikiforov, M. A. (2018). FOXQ1 controls the induced differentiation of melanocytic cells. Cell Death & Differentiation, 25(6), 1040-1049.

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For research use only. Not intended for any clinical use.

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