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Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0850) (CBMAB-F0678-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0850
Antibody Isotype
IgG
Application
WB, IF, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Forkhead Box M1
Introduction
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
2305
UniProt ID
Q08050
Alternative Names
Forkhead Box M1; M-Phase Phosphoprotein 2; Hepatocyte Nuclear Factor 3 Forkhead Homolog 11; Winged-Helix Factor From INS-1 Cells; Forkhead-Related Protein FKHL16; MPM-2 Reactive Phosphoprotein 2; Transcription Factor Trident; HNF-3/Fork-Head Homolog 11; FKHL16; HFH-11; HFH11; MPP2;
Function
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
DNA repair Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Negative regulation of cell aging Source: UniProtKB
Negative regulation of stress-activated MAPK cascade Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of double-strand break repair Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of cell cycle Source: BHF-UCL
Regulation of cell growth Source: UniProtKB
Regulation of cell population proliferation Source: GO_Central
Regulation of Ras protein signal transduction Source: BHF-UCL
Regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.
More Infomation

Kalathil, D., John, S., & Nair, A. S. (2021). FOXM1 and cancer: faulty cellular signaling derails homeostasis. Frontiers in oncology, 10, 626836.

Borhani, S., & Gartel, A. L. (2020). FOXM1: a potential therapeutic target in human solid cancers. Expert Opinion on Therapeutic Targets, 24(3), 205-217.

Ai, C., Zhang, J., Lian, S., Ma, J., Győrffy, B., Qian, Z., ... & Feng, Q. (2020). FOXM1 functions collaboratively with PLAU to promote gastric cancer progression. Journal of Cancer, 11(4), 788.

Cheng, Z., Yu, C., Cui, S., Wang, H., Jin, H., Wang, C., ... & Qin, W. (2019). c irctp63 functions as a cerna to promote lung squamous cell carcinoma progression by upregulating foxm1. Nature communications, 10(1), 3200.

Barger, C. J., Branick, C., Chee, L., & Karpf, A. R. (2019). Pan-cancer analyses reveal genomic features of FOXM1 overexpression in cancer. Cancers, 11(2), 251.

Tan, Y., Wang, Q., Xie, Y., Qiao, X., Zhang, S., Wang, Y., ... & Zhang, B. (2019). Identification of FOXM1 as a specific marker for triple‑negative breast cancer. International journal of oncology, 54(1), 87-97.

Liao, G. B., Li, X. Z., Zeng, S., Liu, C., Yang, S. M., Yang, L., ... & Bai, J. Y. (2018). Regulation of the master regulator FOXM1 in cancer. Cell Communication and Signaling, 16(1), 57.

Nandi, D., Cheema, P. S., Jaiswal, N., & Nag, A. (2018, October). FoxM1: repurposing an oncogene as a biomarker. In Seminars in Cancer Biology (Vol. 52, pp. 74-84). Academic Press.

Chai, N., Xie, H. H., Yin, J. P., Guo, Y., Wang, M., Liu, J., ... & Zhang, R. (2018). FOXM1 promotes proliferation in human hepatocellular carcinoma cells by transcriptional activation of CCNB1. Biochemical and biophysical research communications, 500(4), 924-929.

Penke, L. R., Speth, J. M., Dommeti, V. L., White, E. S., Bergin, I. L., & Peters-Golden, M. (2018). FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis. The Journal of clinical investigation, 128(6), 2389-2405.

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For research use only. Not intended for any clinical use.

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