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Mouse Anti-FOXL2 Antibody (1B4) (CBMAB-0386-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B4
Antibody Isotype
IgG2c
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FOXL2
Introduction
FOXL2 (forkhead box L2) is a forkhead transcription factor containing a fork-head DNA-binding domain. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. FOXL2 may play a role in ovarian development and function.
Entrez Gene ID
668
UniProt ID
P58012
Alternative Names
BPES; BPES1
Function
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity).

Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity).

Is a regulator of CYP19 expression (By similarity).

Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity).

Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Apoptotic DNA fragmentation Source: UniProtKB
Cell differentiation Source: GO_Central
Extraocular skeletal muscle development Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Ovarian follicle development Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES):
A disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold curving in the mediolateral direction, inferior to the inner canthus. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects.
Premature ovarian failure 3 (POF3):
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
PTM
Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
More Infomation

Tucker, E. J. (2022). The Genetics and Biology of FOXL2. Sexual Development, 16(2-3), 184-193.

Dai, S., Qi, S., Wei, X., Liu, X., Li, Y., Zhou, X., ... & Li, M. (2021). Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia. Development, 148(8).

Gan, R. H., Wang, Y., Li, Z., Yu, Z. X., Li, X. Y., Tong, J. F., ... & Gui, J. F. (2021). Functional divergence of multiple duplicated Foxl2 homeologs and alleles in a recurrent polyploid fish. Molecular Biology and Evolution, 38(5), 1995-2013.

Pilsworth, J. A., Cochrane, D. R., Neilson, S. J., Moussavi, B. H., Lai, D., Munzur, A. D., ... & Huntsman, D. G. (2021). Adult‐type granulosa cell tumor of the ovary: a FOXL2‐centric disease. The Journal of Pathology: Clinical Research, 7(3), 243-252.

Shin, E., Jin, H., Suh, D. S., Luo, Y., Ha, H. J., Kim, T. H., ... & Bae, J. (2020). An alternative miRISC targets a cancer‐associated coding sequence mutation in FOXL2. The EMBO journal, 39(24), e104719.

Carles, A., Trigo-Gonzalez, G., Cao, Q., Cheng, S. W. G., Moksa, M., Bilenky, M., ... & Hirst, M. (2020). The pathognomonic FOXL2 C134W mutation alters DNA-binding specificity. Cancer Research, 80(17), 3480-3491.

Pierini, S., Tanyi, J. L., Simpkins, F., George, E., Uribe-Herranz, M., Drapkin, R., ... & Facciabene, A. (2020). Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. JCI insight, 5(16).

Nicol, B., Grimm, S. A., Chalmel, F., Lecluze, E., Pannetier, M., Pailhoux, E., ... & Yao, H. H. C. (2019). RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. Nature communications, 10(1), 5116.

Major, A. T., Ayers, K. L., Chue, J., Roeszler, K. N., & Smith, C. A. (2019). FOXL2 antagonises the male developmental pathway in embryonic chicken gonads. Journal of Endocrinology, 243(3), 211-228.

Nicol, B., Grimm, S. A., Gruzdev, A., Scott, G. J., Ray, M. K., & Yao, H. H. (2018). Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads. Human molecular genetics, 27(24), 4273-4287.

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For research use only. Not intended for any clinical use.

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